Chemotherapy Drugs

Question 1

S phase dependent drugs?

Answer 1

5-FU, 6-MP, Cytarabine, Anthracyclines (doxorubicin), Methotrexate, Procarbazine (5,6-CAMP), hydroxyurea

Question 2

G2-phase dependent drugs?

Answer 2

Bleomycin, etoposide (late S-G2)

Question 3

M phase dependent drugs?

Answer 3

Vincas, taxanes

Question 4

Decreases thymidine synthesis?

Answer 4

5-FU, MTX

Question 5

Antimetabolites?

Answer 5

Folic acid, pyrimidine, and purine analogs

Question 6

Pyrimidine analogs?

Answer 6

5-FU, cytarabine

Question 7

Teratogenic (can cause abortion)?

Answer 7

MTX

Question 8

What is 5-FU bioactivated to?

Answer 8

5F-dUMP–inhibits thymidylate synthase decreasing dTMP

Question 9

Treatment for overdose of 5-FU?

Answer 9

Thymidine rescue

Question 10

What activates 6-MP?

Answer 10

HGPRT

Question 11

Drugs that intercalate DNA?

Answer 11

Dactinomycin and doxorubicin

Question 12

Drugs that cross-link DNA?

Answer 12

Alkylating agents, cisplatin

Question 13

Wilm’s tumor tx?

Answer 13

Dactinomycin

Question 14

Generates free radicals causing breaks in DNA?

Answer 14

1) Doxorubicin

2) Bleomycin

Question 15

Cardiomyopathy type caused by doxorubicin?

Answer 15

Dilated

Question 16

Ewing’s sarcoma tx?

Answer 16

Dactinomycin

Question 17

Fe chelating agent used to prevent cardiotoxicity caused by doxorubicin?

Answer 17

Dexrazoxane

Question 18

1st line for testicular tumor?

Answer 18

Bleomycin

Question 19

Testicular tumor tx?

Answer 19

Etoposide, bleomycin, cisplatin

Question 20

Hodgkin’s tx?

Answer 20

Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazene

Question 21

MOA of cyclophosphamide?

Answer 21

Covalently crosslink (intrastrand) DNA at guanine N-7

Question 22

What drug requires bioactivation by the liver?

Answer 22

Cyclophosphamide

Question 23

Tx for hemorrhagic cystitis?

Answer 23

Mesna

Question 24

Tx for brain tumors?

Answer 24

Nitrosureas (-mustine)

Question 25

Drug causes HSRs?

Answer 25

Taxanes

Question 26

Nephrotoxic?

Answer 26

Cisplatin/carboplatin

Question 27

Acoustic nerve damage?

Answer 27

Cisplatin/carboplatin

Question 28

Peripheral neuropathy?

Answer 28

Vincristine

Question 29

How do you prevent nephrotoxicity caused by cisplatin?

Answer 29

Amifostine (free radical scavenger)

Question 30

Most commonly used glucocorticoid in cancer therapy?

Answer 30

Prednisone, prednisolone

Question 31

MOA of tamoxifen and raloxifene?

Answer 31

SERMS-receptor blocker in breast and agonist in bone (blocks binding of estrogen to estrogen receptor-positive cells)

Question 32

Use for tamoxifen and raloxifene?

Answer 32

Breast cancer tx and prevention, osteoporosis

Question 33

Drug that is partial agonist in endometrium increasing risk of endometrial cancer and hot flashes?

Answer 33

Tamoxifen (not in raloxifene bc it is an endometrial antagonist)

Question 34

MOA of trastuzumab?

Answer 34

Monoclonal Ab against HER-2 (c-erbB2)

Question 35

Ph Chr bcr-abl tyrosine kinase inhibitor?

Answer 35

Imatinib--used for CML

Question 36

Monoclonal Ab against CD20?

Answer 36

Rituximab--for B-cell neoplasms (non-Hodgkin's)

Question 37

Inhibitor of B-Raf kinase in pt with V600E mutation?

Answer 37

Vemurafenib--for mets melanoma tx

Question 38

Monoclonal Ab against VEGF?

Answer 38

Bevacizumab

Question 39

What metabolizes 6-MP?

Answer 39

Xanthine oxidase

Question 40

AEs of MTX?

Answer 40

Myelosuppression, macrovesicular fatty change in liver, mucositis, megaloblastic anemia

Question 41

Used to tx colon cancer?

Answer 41

5-FU

Question 42

Used to tx ALL and AML?

Answer 42

6-MP

Question 43

Causes skin hyperpigmentation but NOT myelosuppression?

Answer 43

Bleomycin

Question 44

Causes skin hyperpigmentation AND myelosuppression 100% of time?

Answer 44

Busulfan

Question 45

Use for busulfan?

Answer 45

CML

Question 46

Used for ovarian and breast cancers?

Answer 46

Taxanes

Question 47

Causes alopecia?

Answer 47

Etoposide

Question 48

Alkylating agents?

Answer 48

1) Cyclophosphamide 2) Nitrosureas (-mustine) 3) Busulfan