Lipid Lowering Drugs Flashcards Preview

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Flashcards in Lipid Lowering Drugs Deck (19):
1

Best at lowering LDL?

Statins

2

Best at raising HDL?

Niacin

3

Best at lowering TGs?

Fibrates

4

2nd line choice for lowering LDL?

Cholesterol absorption blockers (ezetimibe)

5

2 drugs that are hepatotoxic?

Statins and fibrates (increases LFTs)

6

2 drugs that cause cholesterol gallstones?

Fibrates and bile acid resins

7

2 drugs that causes myositis?

Statins and fibrates

8

Exacerbates gout by increasing uric acid?

Niacin

9

Decreases gallstones?

Cholesterol absorption blockers (ezetimibe)

10

Cause of red facial flushing with niacin use?

Increase in prostaglandins

11

How to prevent flushing?

Aspirin

12

2nd line choice for lowering TGs?

Niacin

13

May cause hyperglycemia (acanthosis nigricans)?

Niacin

14

Causes GI discomfort and bad taste?

Bile acid resins

15

MOA of niacin?

Inhibits lipolysis in adipose tissue, reduces hepatic VLDL secretion into circulation

16

MOA of bile acid resins?

Prevents intestinal reabsorption of bile acids-->liver must use cholesterol to make more

17

MOA of fibrates?

Upregulates LPL via stimulation of PPAR-a, which makes HDL cholesterol apolipoproteins; increasing LPL causes TG lysis

18

Why are bile acid resins given with statins?

BARs increase cholesterol synthesis in liver

19

What drug INCREASES triglycerides?

Bile acid resins (NOT GOOD)