Flashcards in Antifungals Deck (10):
Another name for fungal diseases?
Types of Mycoses...
Superficial: affect scalp, nails, skin, mucous membranes, not life threatening.
Systemic: affect internal organs and fatal in immunocompromised.
Commensal: Candida Albans.
Environmental: Aspergillus fumigation / Cryptococcus neoformans.
Anti fungal drug targets:
Fungal Cell Wall - skeletal/matrix components, complex structure, crucial for survival.
Skeletal Cell Wall - Glucan, B1-6 Glucan, B1-3 Glucan, Chitin.
Matrix Cell Wall - Manan
Those at risk of developing fungal infection...
Impaired immune system: HIV, AIDS, transplant, premature, cancer, ICU.
Menstrual cycle in women.
Mechanism of Echinocandins...
Inhibit enzyme B1-3 and block synthesis. Target plasma membrane, containing ergosterol to grow/survive.
Caspofungin / Micafungin.
Mechanism of Polyene Antifungals...
Kill existing cells by binding to ergosterol in plasma membrane, form pores to disrupt membrane integrate > kidney failure.
Examples of Polyene Antifungals...
Amphotericin B - ABLC/ L-ampB formulations.
Nystatin - oral/GI infections.
Mechanism of Azoles...
Inhibit new cell production by inhibiting ergosterol biosynthetic enzymes and blocking biosynthesis causing toxic accumulation, causing growth arrest.
Examples of Azoles...
Imidazoles/ Triazoles - fungistatic, inhibit LC14D, higher affinity for enzyme, more potent.
Allylamines - inhibit earlier stage (Terbinafine, Laminal, Amorolfine)