Antifungals Flashcards Preview

Applied Pharmacology > Antifungals > Flashcards

Flashcards in Antifungals Deck (10):
1

Another name for fungal diseases?

Mycoses

2

Types of Mycoses...

Superficial: affect scalp, nails, skin, mucous membranes, not life threatening.
Systemic: affect internal organs and fatal in immunocompromised.
Commensal: Candida Albans.
Environmental: Aspergillus fumigation / Cryptococcus neoformans.

3

Anti fungal drug targets:

Fungal Cell Wall - skeletal/matrix components, complex structure, crucial for survival.
Skeletal Cell Wall - Glucan, B1-6 Glucan, B1-3 Glucan, Chitin.
Matrix Cell Wall - Manan

4

Those at risk of developing fungal infection...

Impaired immune system: HIV, AIDS, transplant, premature, cancer, ICU.
Menstrual cycle in women.

5

Mechanism of Echinocandins...

Inhibit enzyme B1-3 and block synthesis. Target plasma membrane, containing ergosterol to grow/survive.

Caspofungin / Micafungin.

6

Mechanism of Polyene Antifungals...

Kill existing cells by binding to ergosterol in plasma membrane, form pores to disrupt membrane integrate > kidney failure.

7

Examples of Polyene Antifungals...

Amphotericin B - ABLC/ L-ampB formulations.
Nystatin - oral/GI infections.

8

Mechanism of Azoles...

Inhibit new cell production by inhibiting ergosterol biosynthetic enzymes and blocking biosynthesis causing toxic accumulation, causing growth arrest.

9

Examples of Azoles...

Imidazoles/ Triazoles - fungistatic, inhibit LC14D, higher affinity for enzyme, more potent.
Allylamines - inhibit earlier stage (Terbinafine, Laminal, Amorolfine)

10

RNA/DNA synthesis targeting Antifungals...

Toxic antimetabolite inhibiting RNA/DNA synthesis, high resistance, used with azoles.

Flucytosine.