Arthritis Drugs Flashcards Preview

Applied Pharmacology > Arthritis Drugs > Flashcards

Flashcards in Arthritis Drugs Deck (14):
1

Effect of NSAIDS...

Antipyretic = inhibit PG action on hypothalamus.
Analgesic = reduce neutron sensitivity to bradykinin, effective against muscular/skeletal pain.
Anti-inflammatory = reduce vasodilation and decrease venule permeability.

2

Examples of NSAIDS...

Aspirin - rapidly absorbed in stomach, displaces warfarin bound to plasma proteins which causes anticoagulant activity.
Paracetamol - analgesic/antipyretic, suppressing PG production and stimulate serotonergic pathway.

3

Side effects of NSAIDs...

gastric ulcers, impaired coagulation, GI bleeding, CV events, induce asthma/angiodema/urticarial/rhinitis, kidney damage.

4

Alternatives to NSAIDS...

Misoprostol - synthetic PG given with NSAID to preserve mucous GI lining and ulceration.
Side effect; diarrhoea, vaginal bleeding.

5

What are DMARDS...

Drugs with unrelated structures and different mechanisms of action.

6

Examples of DMARDS...

Methotraxane = folic acid antagonist, inhibit DNA synth, inhibit T cell activation.
Sulfasalazine = scavenge free radicals produced by neutrophils.
Penicillamine = decrease IL1 generation and fibroblast profile to reduce immune response.

7

Side effects of DMARDS...

blood dycrasias, liver cirrhosis, folate deficiency, GI upset, headache, skin reactions, leukopenia, rash, stomatitis, anorexia, taste disturbance, fever.

8

Examples of Gold Compounds...

Auranofin oral = inhibit |IL1 TNFA production to reduce pain/swelling.
Sodium Auranofin inject= concentrates in synovial/liver cells, kidney tubules, adrenal cortex and macrophages.

9

Side effects of Gold Compounds...

rash, flu, mouth ulcer, blood disorder, encephalopathy, peripheral neuropathy, hepatitis.

10

Antimalarials...

Chloroquine / Hydrochloroquine.
Increase pH of intracellular vacuoles to induce apoptosis in T-lymph.

11

Examples of Biological agents...

Anticytokine - surgery.
Adalimumab/Etenercept - inhibit TNFA.
Rituximab- block CD20 on B cells increasing NKC destruction.
Abataceot - prevent activation B cells interfere with APCs.
Toclizumab - block IL6R disrupting immune signals.
JAK inhibitor = oral DMARD
Ofactinub = improve pain, fatigue, soc-emot functioning.

12

Side effects of Biological agents...

Latent disease: TB, Hep B, opportunistic infection, Nausea, abode pain, heart failure and hypersensitivity.

13

Examples of immunosuppressants...

Cyclosporin = potent, no effect on acute inflame. inhibit IL2 gene transcription and decrease T cell.
Azathioprine = interfere with purine metabolism to decrease DNA synthesis. suppress bone marrow.
Leflunomide = inhibit pyrimidine synthesis and T cells.
Cyclophosphamide = inhibit DNA cross linking.

14

Side effects of immunosuppressants...

Nephrotoxicity, hepatotoxicity, hypertension, nausea, gym hypertrophy, GI problems, diarrhoea, alopecia.