Anxiolytics and Antidepressants Flashcards Preview

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Flashcards in Anxiolytics and Antidepressants Deck (26):
1

Types of mood disorder...

Bipolar, depression, unipolar and manic-depressive illness.

2

Symptoms of mood disorders:

Depression: dysphoria, low mood, anhedonia, low energy, fatigue.
Mania: elation, talkativeness, creativity, full energy, confidence.

3

Mechanisms of MOAI...

Non-selective blockers of monoamine metabolism treating depression caused by serotonin/noradrenaline imbalance.

4

Examples of MOAI...

Phenelzineu/Nardil - depression bipolar
Tranylcypromine/Parnate - severe depression.

5

Side Effects of MOAI...

Hypertensive crisis, serotonin syndrome, inhibit P450, weight gain, oedema, sexual dysfunction, sedation, impair renal/hepatic function.

6

Mechanism of Tricyclic Drugs...

Non-selective reuptake of noradrenaline/serotonin increasing availability of transmitters to receptors.

7

Examples of Tricyclic Drugs...

Imipramine/Tofranil - depression
Amitriptyline/Elacil - depression
Dozen/Sinequan - depression anxiety

8

Side effects of Tricyclic Drugs...

weight gain, sexual dysfunction, inhibit P450, sedation, dry mouth, blurred vision, dizziness, headache, constipation.

9

Examples of Selective Serotonin Reuptake Inhibitors...

Fluoxetine/Prozan - depression OCD
Paroxetine/Paxil - depression panic
Sertraline/Zoloft - depression panic
Citalopram/Celexa - depression

10

Side effects of SSRIs...

sexual dysfunction, dependence, weight loss, serotonin syndrome, agitation, disorientation, ataxia, muscle spasms, exaggerated autonomic function, drug interaction BZD/cimetidine/warfarin.

11

Third Generation Antidepressants...

Bupropion.Wellbutri - aminoketone inhibits serotonin/noradren/dopamina reputare.

12

Examples of Mood Stabilisers...

Lithium carbonate/Eskalith lithoid - acute main prophylaxis
Lithium citrate/Cibalith - acute mania prophylaxis
Carbamazepine/Tegretol - main epilepsy
Valproate/Depaxcon - mania epilepsy

13

Side effects of Mood Stabilisers...

Drug interactions, dizziness, headache, confusion, oedema, hair loss, cardiac disarrythmias, nephrotoxicity, acute mania on withdrawal, anti-convulsants, weight loss, birth deformities.

14

Other ways of treating depression...

ECT, CBT, counselling, psychotherapy.

15

Mechanism of Anxiolytics...

Non-specific CNS depressants alleviating distress.

16

Examples of sedative-hypnotics...

Thiopental/Pentothal - prepare for surgery.
Secobarbital/Seconal - insomnia agitation.
Phenobarbital/Luminal - insomnia, seizures.
Zolpidem/Ambien - insomnia

17

Side effects of sedative-hypnotics...

suicidal tendencies, drowsiness, hangover, respiratory failure, dependence, seizure.

18

Examples of Benzodiazepines...

Diazepam/Valium - anxiety stress.
Alprazolam/Xanax - anxiety panic
Temazepam/Restoril - short term insomnia
Lorazepam/Ativan - anxiety, status epileptics, pre-op sedation, amnesia.

19

Side effects of Benzodiazepines...

accumulation of metabolites, over sedation, CNS depression, ataxia, headache, dry mouth, blurred vision, dizziness, memory loss, hypotension, G| disturbances.

20

Examples of Non-Benzodiazepine

Buspirone/BuSpar - anxiety, depression, short term.

21

Side effects of Non-Benzodiazepines...

dizziness, headache, insomnia, nausea, dry mouth, blurred vision, mood change, palpitations.

22

Symptoms of Schizophrenia...

+ = hallucinations, delusions, bizzarre thought.
- = social withdrawal, flattened mood, apathy.
difficult to understand, disorganised and unable to distinguish between real/unreal experiences.

23

Examples of Antipsychotics (D2 receptor antagonists)...

Chlorpromazine/Thorazine - psychosis, schiz, child behaviour.
Fluphenazine/Prolixin - psychosis, schiz.
Haloperidol/Haldol - psychosis, severe behaviour.
Loxapine/Loxitane - mood management, schiz.

24

Side effects of D2 receptor antagonists...

parkinsonism, tremor, akinesia, muscle rigidity, sedation, hypotension, impaired thermoregulation, lactation, neuroleptic malignant syndrome.

25

Examples of Atypical Antipsychotics...

Clozapine/Clozaril
Amisulphride/Solian
Risperidone/Risperfal
Onlazepine/Zyprexa

26

Side effects of Atypical Antipsychotics...

neuroleptic malignancy, headache, blurred vision, insomnia, photosensitivity, nervousness, dizziness, GI distress, glaucoma, urinary retention, peptic ulcer, dysrhythmias, hepatic dysfunction, weight gain.