Flashcards in Antigen Presentation Deck (90)
What is the term for something that causes the immune system to create antibodies specifically targeting that something?
What is the term for an antigen that a given B cell's receptors recognize?
What is the part of the antigen that the antibody recognizes and attaches?
What is the part of the antibody that recognizes and attaches to the epitope?
What does MHC stand for?
Major Histocompatibility Complex
Which MHC is associated with almost all cells of the body?
Which MHC allows us to see what is being made in the cells?
Which MHC is only associated with antigen presenting cells?
Special cells eat protein (phagocytosis) outside of the cell, break it down, and present the fragments on the cell surface. Which MHC is associated with this process?
Cells constantly break down proteins created within the cell and present them on the cell surface. Which MHC is associated with this?
What are endogenous proteins?
proteins made in the cell
During Antigen presentation by MHC I, what type of proteins are constantly being broken down into fragments?
What are cytotoxic lymphocytes associated with anitgen presentation by MHC I?
Killer T cells
During antigen presentation by MHC I, what are responsible for constantly inspecting the presented fragments?
Cyotoxic lymphocytes (Killer T cells)
What molecules bind to protein fragments created in the cell and bring them to the surface of the cell?
Which MHC is most like a constantly updating billboard that advertises what is being made in the cell?
What kind of proteins are presented by MHC I?
ordinary cellular proteins (enzymes and structural), proteins encoded by viruses and parasite proteins
What cells express MHC I molecules?
almost every cell in the body
What do proteasomes constantly chew up?
cellular protein (normally deal with defective proteins)
What are peptides?
T/F: Some peptides are brought to the endoplasmic reticulum where they are attached to MHC II molecules.
False; they brought here to attach to MHC I molecules
Where is the peptide-MHC I complex transported?
to the cell surface
What are the specific transport proteins for MHC I molecules named?
TAP 1 and TAP 2
T/F: most peptides are broken down into individual amino acids and excreted as wastes.
False: they are broken down but for the purpose of reuse
How many MHC I genes are there?
6; 3 from mom, 3 from dad
What are the three main gene variants for MHC I?
HLA-A, HLA-B, and HLA-C
T/F: MHC I molecules have an ability to bind many different kinds of peptides.
How long are most peptides that bind to MHC I molecules?
8-11 amino acids long
T/F: peptides bound to MHC I molecules are anchored at only one end.
False; they are anchored at both ends