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1

What do Tk cells do?

kill other cells

2

What do Th cells do?

help other cells

3

Where are T cells made?

bone marrow

4

Where do T cells mature?

in the thymus (T for thymus)

5

T/F: T cells circulate in the blood and lymph.

true

6

T/F: T cells cannot enter tissue

false; they can

7

What are the antibody like receptors on the surface of T cells called?

T cell receptors (TCRs)

8

What do TCRs specialize in?

recognizing protein antigens presented by MHCs (this means the antigen is a peptide)

9

T/F: there are about 300 million T cells in the body on average.

False; 300 billion, with a B.

10

What are killer T cells also called?

cytotoxic T cells (CTLs)

11

How are killer T cells activated?

by MHC I being presented on cells

12

T/F: most cells in the body can present antigens to CTLs via MHC class II molescules.

False; should say MHC I molecules

13

What connects to the target cell and triggers it to commit suicide killing the cell and the virus inside it?

Killer T cells/CTLs

14

What activates Helper T cells (Th)?

MHC II on Antigen Presenting Cells (APCs)

15

What is secreted by Helper T cells?

cytokines IL-2 and IFN-y (interferon gamma)

16

What kind of cells keep the immune system from overreacting?

Regulatory T cells

17

T/F: regulatory T cells are probably the one part of the immune system that we know the most about.

False; much is still unknown about regulatory T cells

18

T/F helper T cells do not require activation to perform their function.

False; both helper and killer T cells require activation

19

What kind of cells help Helper T cells?

APCs (activated dendritic macrophage and B cells)

20

What must a TCR recognize in order to be activated?

cognate antigen

21

What must the Co-receptor recognize in order for activation to occur?

MHC (either I or II)

22

What happens during Co-stimulation?

other receptors recognize other molecules (besides for cognate antigens and MHCs)

23

T/F: more is known about Helper T cell activation than Killer T cell activation.

True (think alphabetical order)

24

What happens to T cells that see "self" being presented by other cells?

These die. T cells that would kill self need to go away.

25

How are T cells anergized?

When T cells recognize self antigen, but do not get co-stimulated they will be rendered inactive or anergized.

26

What happens to a T cell that sees non-self and gets co-stimulated?

activation

27

What happens when a TCR recognizes MHC plus self peptides?

T cell commits suicide (apoptosis)

28

What happens when TCR recognizes cognate antigen on MHC with no co-stimulation?

T cell is anergized (inactivated)

29

What happens when TCR recognizes cognate antigen on MHC plus co-stimulation?

T cell is activated

30

T/F: T cells recognize MHC I and/or MHC II molecules.

False; T cells only recognize peptides presented by MHC molecules