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Flashcards in Antihelmintics ll Deck (18)
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1

against which types of creatures do these drugs act

-roundworms (nematodes)
-tapeworms (cestodes)
-flukes (trematodes)

2

Name all 9 groups of drugs with antihelmintic act. (9)

-benzoimidazoles and probenzimidazoles
-macrocyclic lactones
-imidazothiazoles
-isoquinolin and benzazepin derivates
-organophosphates
-piperazines
-tetrahydeopyrimidines
-salicylanilides and substituted phenols
-others

3

Name the most imp. Salicylanides and substituted phenols (4)

-closantel
-oxyclozanide
-rafoxanide
-Nitroxinil

4

describe moa for salicylanilides and subst. phenols

uncoupling of oxidative phosphorylation - allowing hydrogen ions to leak through mitoch. membrane

5

in which species are these used against fasciolosis

cattle and sheep

6

what are they generally inactive against

nematodes

7

what is the efficacy against immature flukes

lowered

8

What is an important pk factor for these drugs

half life

9

what is the half life of these drugs like

long as there is sign. plasma prot. binding

10

Do they need wp

yes long wp

11

Which is excreted in bile duct

oxyclozanide

12

Why ar3 mature flukes more susceptible

because as they grow they cause haemorrhaging and get in contact with the antihelmintics that way

13

hat are some side effects of these drugsq

high dosages may cause blindness, hyperthermia, convulsions and death

14

Name the isoquinolin and benzazepin derivates

praziquantel
epsiprantel

15

mao of isoquinolin and benzazepin derivates

induction of spastic paralysis - interfering with ca ccq

16

What are the worms targeted by isoquinolin and benzazepin

cestodes

17

what is the spectrum of bunamidine salts

tape worms cestodes

18

moa of bunamide salts

leads to digestion of tapeworm in the gut of the host due to an inhib of glucose uptake of worms