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Flashcards in Autonomic NS & Drugs Deck (80)
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1

main neurotransmitter of the parasympathetic ns

acetylcholine

2

how to synth. ach

acetyl coa + choline

3

Which ion is needed to cause a action potential at a synapse?

Na+

4

what does acetylcholine cause

-myosis
-salivation
-bradycardia
-branchi bladder constr.
-stimulates GI
-inhibits glucose release

5

primary neurotransmitter of sympathetic NS

Noradrenaline(catecholamine)

6

Synth. of NE

phenylalanine > tyrosine > dopamine > NE > E

7

What does NE

-mydriasis
-slows salivation
-tachycardia
-relaxes bronchi, bladder
-inhibtis GI
-releases Gluc.

8

Which Ach receptor types are there

muscarinic, nicotinic

9

Which antagonists inhibit which receptor

-MAch - Atropine
-NAch - Curare

10

Name all the direct parasympathomimetics (5)

-Ach
-Bethanachol
-Pilocarpine
-Carbacol
-Methacholine

11

Name all the of the indirect parasympathetics (5)

-Physostigmine
-Pyridostigmine
-Neostigmine
-Edrophonium
-Organophsophates

12

Name 4 of the 8 parasympatholytics

-atropine
-tropicamide
-Ipratropium
-Butyl-scopolamine
-Glycopyrrolate
-Homatropine
-Benzethemide
-Levodopa

13

Which of the 2 Ach rec is a simple ion channel

Nicotinic

14

What kind of rec. is Muscarinic

G-protein

15

How many types of MAch rec are there

3

16

Where can you find which type of MAch rec.

M1,M3 - stomach, bronchi, eye, vessel
M2 - heart

17

Cholinergic

parasympathimimetics

18

Anticholinergic

parasympatholytics

19

Ach has a long T1/2 t/f

f only 2 mins

20

Name the parasympathomimetics that bind non specific

-Ach
-Carbachol

21

What is Carbachol used for

-esp. swine emetic and eye drops

22

which direct parasympathomimetcs are specific for MAch

-Bethanechol
-Methacholine

23

ind. for bethanechol

-int. peristalsis
-urinary bladder paralysis

24

What is pilocarpine used in

glaucoma and KCS

25

how do the indirect sympathomimetic act

they inhibit Ach esterae and create more Ach in synapse

26

What are possible side effects of indirect parasymp.

-in NAch - excess Ach - muscular spasms
-in MAch - build up can cause bradycardia, myosis
-mental effects of high Ach dose

27

What does Ach esterase do

hydrolyses Ach into acetic acid and choline

28

Characterize physostigmine

-lipophilic
-high abs. and penetration within GI
-easy to overdose
-used for atropine poisoning and glaucoma

29

Neostigmine is absorbed how?

not in GI only IV or IM

30

Does Neostigmine cause BBB

no