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Flashcards in Glucocorticoids Deck (25)
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1

what are glucocorticoids

steroid hormones that bind to the glucocorticoid rec.

2

how does the adrenal cortex synth. glucocort.

steroid base - cholesterol - pregnenolone - corticosteroid

3

Name the corticosteroid types

-glucocorticoids
-mineralocorticoids
-androgens

4

What stimulates the prod of the corticosteroids and where is it produced

Acth ex pituitary gland (hypophysis)

5

What percent of cortisol is bound to plasma protein












90%

6

what are the main sites of peripheral cortisol met.

liver and kidney

7

to which rec do the gc s bind

to the cytosolic glucocorticoid receptor

8

how is the gc being bound to the rec.

as it is lipophilic it goes across the cell membrane where it is bound to the cytosolic glucocorticoid rec. and travels to the nucleus in bound form where it is either repressed (by HAT activated in inflam.) or activated and genes are transcribed

9

What does the activation of gc lead to

encoding of antiinflam. mediators:
-ANNEXIN
- interleukin 10
...

10

name the effects of gcs on carbohydrate met.

-stimulated gluconeogenesis, incr. glucogenolys.
-inhib. gluc transport into cells and incr. insulin resistance
-incr. blood sugar level

11

effects of gcs on lipid met.

-incr. lipolysis, high levels of ffa
-incr. lipogenesis and redistr. of fat - leads to obesity

12

protein met effects of gcs

anti anabolic, catabolic action
-decr. epithelium reg.
-decr. wound healing

13

effects of gcs on water-electrolyte balance

-smaller doses - incr. diuresis
-larger doses - Na and water retention

14

effects of gcs on bones

-anti vit d action
-incr. CA excr.

15

effects of gcs on cv

incr. BP

16

effects of gcs on blood cell formation

-slightly incr. red blood cell formation
-slightly incr. white blood cell form.

17

anti inflam. action of gcs

-inhibit action of cox 2 and formation of prostaglandins
-induce synth. of lipocortins - mediate anti infl.
-stim. endogenous anti-infl. pathways
-syn. of eicosanoids decr.
-t-cell and phagocyte activity decr.

18

name the types of gcs

-long acting
- med. acting
-short acting

19

Name the short acting gcs

-Cortisol
-Cortisone (inactive needs liver activation)

20

Name the med acting gcs

-prednisolone
-methylprednisolone
-triamcinolone

21

name the long acting gcs

-dexamethasone
-betamethasone
-flumethasone

22

Name all the ind. for gcs (10)

-anti infl.
-oedema
-shock
-allergy, anaphylaxis,
-asthma
-autoimmune disorder
-lymphoid tumor
-induction of praturition
-ketosis
-addisons disease

23

Name the SE of gcs

-inhib. of wound healing
-neg. effect on nutrient and mineral met.
-immunosuppression
-- reactivation of preexisting cond.
-catabolic effect - diabetogenic, muscle wasting, osteoporosis

24

name the contra ind.

-pre existing renal impairment, chf, liver disease
-diabetes
-pregnancy
-infection
-NSAID treatment (some combis exist)

25

How to admin gcs

-single large dose
-depot
-chronic