Drug Toxicity Flashcards Preview

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Flashcards in Drug Toxicity Deck (4)
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1

How can drug toxicity be measured

-TI
-MOS (margin of safety)
-LD50 / TD50

2

Which adverse effects can occur

- on target
-off target
-toxic metabolites
-harmful immune response
-idiosyncratic

3

How can toxic metabolites be produced

-lipid peroxidation
-reactive oxygen species
-depletion of glutathione

4

Which types of hyper-immune responses are there

Type 1: immediate hypersens. (IgE)
Type2: Ab dep. cytotoxicity
Type3: Immune complex mediated
Type4: delayed hypersens