antiviral pharmacology Flashcards Preview

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Flashcards in antiviral pharmacology Deck (13):
1

what is the mechanism of action of acyclovir?

competes with deoxyGTP for viral DNA polimerase and becomes incorporated into the replicating viral DNA chain ==> causes DNA SYNTHESIS TERMINATION

2

what type of anti-viral drug is monophosphorilated by vial thymidine kinase in infected cells and then activated to a triphosphate form by host cellular kinases in order to be inserted into newly synthesizing DNA?

guanisine analogues
acyclovir
famiciclovir
valcycloive

3

what drug can be used for CMV in immunocompromized pts?

ganiciclovir or it's prodrug (valganiciclovir) which has better bioavailability

4

what are the major side effects of the guanisine analgogues (e.g. acyclovir)?

obstructive crystalline nephropathy and acute renal failure

5

what can be used to prevent renal toxicitiy from acyclovir?

maintain hydration

6

what is the major side effect of ganciclovir?

bone marrow suppression and renal toxicity

7

What is the mechanisms of resistance to acyclivir?

mutated viral thymidine kinase

8

what is the mechanism of action of foscarnet?

FOScarnet inhibits viral DNA/RNA polimerase and also inhibits HIV reverse transcriptase by competing for pyroFOSphate binding site

used for acyclovir-resistant HSV

9

what is hte mechanism of resistance for foscarnet?

FOScarnet work by allosterically inhibiting viral polymerases (binds to pyroFOSphate binding site), so virsuses with mutated DNA polymerases can be resistant

10

What are the main side effects of foscarnet?

nephrotoxicity, electrolite imbalances, SEIZURES!

11

What antiviral drug preferentially inhibits viral DNA polimerase, does not require phosphorilation by viral kinase, causes nephrotoxicity and is not foscarnet?

cidofovir/tenovir

12

what should be given with cidofovir/tenovir to prevent toxicity?

probenecid + IV saline

*probenecid inhibits organic anion transport in the renal proximal tubule

13

What is the mechanism of the drug you would give a pt with acute changes in mental status, seizures, headache, CSF with hemorrhagic lymphocytic pleocytosis with incraesed protein and normal glucose?

MRI shows abnormal MRI signal in bilateral tempral lobes?

pt has HSV encephalitis

give acyclovir - guanisine nucleotide analgogue - competes for viral DNA polimerase for incorporation into replicating DNA and causes chain sysnthesis termination. Must be activated by viral thymidine kinase then phosphorilated to triphosphate form by host cell enzymes

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