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Flashcards in Tumor markers Deck (10):
1

PSA (Prostate-specific antigen)

Normal Function = Liquefaction of semen

Prostate carcinoma
also released with BPH and prostatitis
increase in bound PSA (as compared to free PSA) is suggestive of cancer

2

Prostatic acid phosphatase

Prostate carcinoma

3

α-fetoprotein (AFP)

Normal Function = fetal albumin

Hepatocellular carcinomas
Nonseminomatous germ cell tumors of the testis
e.g. yolk sac tumor

4

β-hCG


Hydatidiform moles
Choriocarcinomas
Gestational trophoblastic tumors

5

CA-125

Released by peritoneum with irritation (can be elevated in endometriosis)


Ovarian cancer
Epithelial tumors

6

TRAP (Tartrate-resistant acid phosphatase)

Hairy cell leukemia

7

CA-19-9

Pancreatic adenocarcinoma

8

S-100


Melanoma
Neural tumors
Astrocytomas

9

Alkaline phosphatase


Marker of bone formation
osteoblastic metastases to bone (e.g. prostate)
Paget's disease of bone
Also released when bile ducts are damaged
obstructive biliary disease

10

Bombesin


Neuroblastoma
Lung cancer
Gastric cancer

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