immunosupressant pharmacology Flashcards Preview

STEP 1 > immunosupressant pharmacology > Flashcards

Flashcards in immunosupressant pharmacology Deck (14):
1

what are the calcineurin inhibitors and what is their mechanism of immunosupression after transplant?

cyclosporine and tacrolimus

block T-cell activation by preventing IL-2 gene transcirption


cause dose dependent rise in BUN and creatinine

2

what is the major adverse drug effect from cyclosporine and tacrolimus?

Highly nephrotoxic

cause dose dependent rise in BUN and creatinine from renal alrteriolar vascocronsitction ==> hypertension and can lead to oblertative vasculopathy

3

what is the mechanism for sirolumus?

aka rapamycin - mTOR inhibitor
blocks T-cell activation and B-cell differentiation by preventing a response (blocked mTOR signal cascade) from binding of IL-2 to its receptor

4

what are daclizumab and basilizimab?

monoclonal antibidies against IL2

5

what drug using in transplant immunospression/rejection prevention works by inhibiting lymphocyte proliferation by blocking nucleotide synthesis?

azathioprine

antimetabolite pre-cursor of 6-mercaptopurine

6

what drug should azathioprine not be given with?

allopurinol - 6-MP metabolite is also degraded by xanthine oxidase --- so increases marrow suprpession when given with allopurinol

7

which immunosupressant works by inhibiting NF-kB and thereby supresses both B and T cell function by decreasing transciption of cytokiness / induces apoptosis

corticosteroids

8

pt with kidney transplant develops avascular necrosis of the femoral head. What was the drug?

prednisone

9

what drug revsrsibly inhibits IMP dehydrogenase, thereby preventing purine synthesis of B and T cells?

mycophenolate mofetil

10

pt received kidney tansplans and took immunosupressant that was associated with an invasive CMV injection - what was the drug?

mycophenolate mofetil

11

pt received kidney tansplans and took immunosupressant developed gingival hyperplasia. what was the drug?

cyclosporine

12

what is anakinra?

IL-1 receptor blocker

13

does rutuximav affect pre-B lymphocytes or plasma cells?

NO only CD20+ mature B cells in the ciruclation

14

which drug inhibits calcineurin, thereby decreasing transcirption of the IL-2 gene in T cells

cyclosporine

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