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Flashcards in random pharmacology Deck (16):
1

what is eflornithine? MOA, used for?

ornithine decarboxylase inhibitor - interrupts DNA stabilization and rapair - leads to decreased cell growth and increased apoptosis

-used to decrease rapidly growing hair

2

what is dantrolene? MOA, used for?

ryanodine receptor blocker - prevents calcium release from sarcoplasmic reticulum and functions as a post-synaptic muscle relaxant.

3

what is metoclopromide? MOA, used for, side effects?

dopamine receptor antagonist used for nausea or vomiting or potentially GERD

MAJOR RISK FOR NEUROLEPTIC MALIGNANT SYNDROME

treat with bromocriptine or amantidine

4

what is pramipexole? MOA, used for?

dopamine agonist used for restless leg syndrome

5

what is ropinirole? MOA, used for?

dopamine agonist used for restless leg syndrome

6

what is akathisia? what can cause it?

restless urge to move appendages
consequence of antidopaminergic antipsychotics

7

what is the treatment for antidopaminergic antipsychotic induced-akathisia?

beta-blockers e.g. propranolol

8

what is used for treatment of cataplexy (sudden loss of muscle tone associated with narcolepsy)?

muscarinic antagonists - e.g. atropine

9

what drug antagonises affect of ADH on priciple cells in the collecting duct resulting in nephrogenic diabedes insipidus?

lithium

10

procainamide
hydralazine
isoniazid

all can cause what condition?
what is the shared property of these drugs that's implicated?

drug-induced lupis with anti-histone antibody positivity

all metabolized by phase II acetylation in the liver via N-acetyltransferase

slow acetylators are at greatest risk for developing acute DILE and specifically peripheral neuropathy from isoniazid

11

what's the equation for half life?

t1/2= 0.7 x Vd / clearance

12

what's the formula for clearance?

clearance = 0.7 x Vd / t1/2

13

what is acitretin?

synthetic retinoid used topically for psoriasis - don't mix with alcohol, forms 120 day metabolite that's highly teratogenic

14

what is sulfasalazine?

disease modifiying anti-rheumatic drug used in psoriatic arthritis

causes jaundice in breast fed infants

15

what is calcipotriol?

vitamin D analogue used in psoriases (topically)

16

what drugs are contraindicated in psoriasis treatment?

tertracycles - may worsen disease

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