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STEP 1 > oncogenes > Flashcards

Flashcards in oncogenes Deck (15):
1

BCR:ABL
BCL-2
CCND1
C-Myc
L-Myc
N-MYC
ERB-B2
CDK4
RET
C-KIT
RAS

CML - 9;22 translocation
Follicular lymphomas - 14;18 translocation
Mantle cell lymphomas - 11;14 translocation
Burkitt's lymphoma - 8;14 translocation
Lung tumor amplification
Neuroblastoma amplification
Breast, ovarian, and gastric carcinomas amplification
Melanoma amplification
Multiple endocrine neoplasia IIA and B point mutation
Gastrointestinal stromal tumor (GIST) point mutation
Colon carcinoma point mutation

2

CML
Follicular and undifferentiated lymphomas
Mantle cell lymphomas
Burkitt's lymphoma
Lung tumor
Neuroblastoma
Breast, ovarian, and gastric carcinomas
Melanoma
Multiple endocrine neoplasia IIA and B
Gastrointestinal stromal tumor (GIST)
Colon carcinoma

BCR:ABL 9;22 translocation
BCL-2 14;18 translocation
CCND1 11;14 translocation
C-Myc 8;14 translocation
L-Myc amplification
N-MYC amplification
ERB-B2 amplification
CDK4 amplification
RET point mutation
C-KIT point mutation
RAS point mutation

3

CML

BCR:ABL 9;22 translocation

4

Follicular and undifferentiated lymphomas

BCL-2 14;18 translocation

5

Mantle cell lymphomas

CCND1 11;14 translocation

6

Burkitt's lymphoma

C-Myc 8;14 translocation

7

Lung tumor

L-Myc amplification

8

Neuroblastoma

N-MYC amplification

9

Breast, ovarian, and gastric carcinomas

ERB-B2 amplification

10

Melanoma

CDK4 amplification

11

Multiple endocrine neoplasia IIA and B

RET point mutation

12

Gastrointestinal stromal tumor (GIST)

C-KIT point mutation

13

Colon carcinoma

RAS point mutation

14

what is the function of ras

signal transducer

15

what is the function in neoplasia of HER2/neu

growth factor receptor upregulation

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