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Flashcards in Antivirals Deck (21):
1

Role of pharmacotherapy in treatment with Peramivir

Only for critically ill or immunocompromised

- NA inhibitor for Influenza A and B

2

Amantadine (Symmetrel) Route of administration

Orally with accumulation in lungs

-Rimantadine is also

3

Rimantadine (Flumadine) Route of administration

Orally with accumulation in lungs

- Amantadine is also

4

MOA: describe different Kinases involved in TPing for acyclovir, ribavirin, and ganciclovir

Acyclovir - TP via viral thymidine kinase

Ribavirin - TP via cellular kinase

Gancyclovir - TP by viral UL97

5

Oral Acyclovir role of pharmacotherapy in treatment:

Oral ↓ symptom duration during primary and
recurrent genital herpes (NOT time to healing).
Need higher doses for varicella or shingles,
but decreases duration.

6

Topical Acyclovir role of pharmacotherapy in treatment:

Topical less effective. Good for 2ndary prevention.

7

Penciclovir (Denavir)
role of pharmacotherapy in treatment:

Rx HSV and VZV

- famciclovir is as well

8

Mechanism of action
Ribavirin

Converted to ribavirin-TP by cellular kinases.
1) Inhibits 5' capping of viral mRNA, ↓stability and translatability
2) ↑viral suicide

9

Adverse Drug Reactions
Ribavirin

Hemolytic anemia. When given with interferon, causes cough, rash and pruritus.

10

role of pharmacotherapy in treatment:
Ribavirin copegus

RSV infxn in bone marrow transplant and other immunocompromised, Rx for Hepatitis C when combined with interferon-α2a

11

role of pharmacotherapy in treatment:
Ribavirin Virazole

Rx for RSV and pneumonia in severe RSV and immunocompromised

12

ROA of Valganciclovir and cidofovir

IV for both

to treat CMV

13

Adverse drug rxns of cidofovir

Nephrotoxicity

14

Role of pharmacotherapy in treatment
Cidofovir

good for CMV infxns if resistant to ganciclovir/foscarnet, or HSV if resistant to acyclovir

15

IV ganciclovir role of pharmacotherapy in treatment

Rx of chronic CMV retinitis in immunocompromised patients. Control CMV in transplant patients.

16

Topical ganciclovir role of pharmacotherapy in treatment

Topical treats HSV keratitis.

17

Oral ganciclovir role of pharmacotherapy in treatment

Oral has some benefit for HBV

18

MOA of foscarnet

Does not require cellular activation. Non-competitively binds RNA and DNA pol to inhibit cleavage of pyrophosphate. Block viral replication

19

ROA of foscarnet

IV
to treat CMV

20

Adverse Drug Reactions
of foscarnet

Nephrotoxicity (renal impairment) and

Electrolyte imbalance (hypocalcemia).

Some CNS abnormalities, rash, fever, nausea

21

Adverse drug rxns of ganciclovir

bone marrow despression/ myelosuppression