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Flashcards in Practice 1 Deck (33):
1

What benign neoplasm stains with Glut-1?

Infantile hemangioma

- if mom underwent chronic villi sampling, it could increase risk of these strawberry hemangiomas

2

What mutation is associated with Port wine stain?

GNAQ

(does not stain with Glut 1 like infantile hemangioma!)

3

How do glucocorticosteroids work?

Inhibition of NF-kappa B

4

What disease causes increased pigmentation?

addisons disease

*darker skin than sister.

5

What is seborrheic dermatitis associated with?

Neuro disorders (parkinsons)
Head trauma
PTSD
HIV

6

When you see "velvet neck" think ___________
- what can cause it?

Acanthosis nigricans

- familial
obesity
endocrinopathies
drugs
cancer ***red flag - rapid weight loss

7

night sweat, red spot on palms (janeway lesions), osler nodes, black streaks in nails (hemorrhagic splinters)

infective endocarditis

8

tightness around mouth, SOB, salt and pepper changes, raynauds
- what disease can it be?
- how can you dx it?

systemic scleroderma

ANA+ in 80-90%

* that poor lady in clinic
- pulm/card involvement

9

itchy rash with ulcers with white lace around in the mouth (mucosa)
- How can you make sure?

lichen planus

Look for the signs "4 Ps of lichen planus"
- puritic
- polygonal
- purple papule

10

What do we have to worry about for lichen planus?

hepatitis C

11

If a pt was suspected of nec fasc --> was treated --> gets worse, what is the disease probably?

pyoderma gangrenosum
(expanding ulcer)

- pathergy: the more you injure it the more it gets worse

12

Pathergy
- what is it
- what disease is associated with it?

The more you injure it, the more it gets worse

- pyoderma gangrenosum

13

Most pts 50-70% of pts with pyoderma gangrenosum have what underlying condition?

inflammatory bowel disease

- 2nd most common is ulcerative colitis or crohns

14

Nails are curled in
- name

koilonychia

15

wood grain on the chest, think ________

lung cancer

16

Shawl sign, think ______

dermatomyositis

17

Which viruses require RdRp?

All (-) strand RNA viruses and double-strand RNA viruses

18

Viral attachment and subsequent entry into cells generally occurs through specific or non-specific interactions with the lipid by-layer??

Specific (otherwise we would be double screwed) think about their glycoproteins!

19

How do interferons respond to viral infxns?

Interferons induce cellular resistance to viral replication
- IFNs (interferes with viral infection of neighboring cells) which induces the anti-viral state.

20

Are Interferons generally directly toxic to viruses?

no

Interferons induce cellular resistance to viral replication
- IFNs (interferes with viral infection of neighboring cells) which induces the anti-viral state.

21

Adverse Drug Reactions of acyclovir

IV → Encephalopathy Renal toxicity w. IV route

22

What do plaque assays measure?

A. Infectivity of a sample

23

acute local disease (ie: common cold)
- incubation period
- virus shedding and transmission
- host responses
- likelihood of re-infection

- incubation period: short
- virus shedding and transmission: many serotypes are rapidly mutating, resulting in short lived immunity
- host responses: secretory IgA
- likelihood of re-infection: common

24

acute systemic disease (ie: measles)
- incubation period
- virus shedding and transmission
- host responses
- likelihood of re-infection

- incubation period: long
- virus shedding and transmission: primary infxn in epithelium but can result in 2nd replication sites
- host responses: secretory IgA and serum IgG
- likelihood of re-infection: low

25

Short-lived immunity (primarily secretory IgA) is associated with acute systemic or acute local disease?

acute local

26

Is it recommended for immunocompromised individuals to receive the influenza vaccine?

influenza vaccine is inactivated so it doesnt matter

(unlike the chicken pox VZV one!)

27

Varicella-zoster virus (VZV) primary infection is BEST characterized as acute local or acute systemic infxn?

Acute systemic infection

28

Amantadine targets which of the following stages of the life cycle of influenza virus?

Viral uncoating

29

. Acyclovir preferentially targets which of the following enzymes for its antiviral activity?

Viral DNA polymerase

30

Caspofungin does/does not? directly target ergosterol pathways

does not

-

31

Drug BEST for P. jirovici (carinii) pneumonia in AIDS patients.

Pentamidine

32

Dimorphic: fungi

o Some Can Have Both Phases = (For thermal dimorphic species)
§ Sporothrix schenkii
§ Coccidioides immitis
§ Histoplasmosa capsulatum
§ Blastomyces dermatitides
§ Paracoccidiodes brasiliensis

33

. Katayama fever corresponds to which of the following aspects of schistosomiasis?

Worm maturation and laying of eggs