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Flashcards in Practice exam 2 Deck (35):
1

Sturge Weber syndrome
- distribution?

Associated with Port Wine Stain where 10-15% of the capillary malformation is V1 distribution. Thus can casue ocular (glaucoma) and neurologic abnormalities (seizures)

2

What would you use to treat infantile hemangioma?

It has lots of complications remember?

Treat with Beta blockers to decrease angiogenesis

3

Which of benign tumors originates from oil glands?

Sebaceous hyperplasia

*note: Common. Increases frequency after middle age. Could be sunlight induced. Distributes face >trunk> extremities

4

p53

tumor suppressor

5

Skin diseases due to defect in filaggrin

atopic dermatitis
ichthyosis

6

Malassezia Furfur is the causative agent for which two skin disorders?

Tina versicolor and seborrheic dermatitis

7

Epidermolysis Bullosa

error in gene encoding the protein type VII collagen

8

Disease BEST characterized as an acquired one involving antibodies to cell-to-cell adhesion molecules in the stratum spinosum?

Pemphigus vulgaris

9

First thing that comes to mind:

A. Icthyosis vulgaris –
B. Ehlers-Danlos syndrome:
C. Vitiligo -
D. Pseudoxantoma elasticum –
E. Solar elastosis –


A. Icthyosis vulgaris – filaggrin – dry and skin breaks up
B. Ehlers-Danlos syndrome - contortionist (congenital collagen production mutation)
C. Vitiligo - prob with melanocytes
D. Pseudoxantoma elasticum – elastin (chicken skin)
E. Solar elastosis – elastin (old people)

10

holocrine (whole cell) gland secretion?

holocrine means whole cells
Sebaceous glands (think zit thing - sebum)

11

A patient presents with evidence of palpable purpura and a diagnosis of leukocytoclastic vasculitis is made. Which of the following types of immune reaction types is BEST exemplified by this condition?

Type III—immune complex mediated

12

immune reaction type that is BEST exemplified by the disease bullous pemphigoid?

Type II—antibody mediated - hemidesmo

13

immune reaction type that is BEST exemplified by a nickel allergy?

Type IV—delayed type hypersensitivity – allergic contact dermatitis

14

primarily located where?
- eccrine
- apocrine
- apoeccrine

- eccrine: everywhere, but mostly face, hands, feet
- apocrine: armpit, urogenital
- apoeccrine: armput

15

___________ glands secrete nearly ten times as much sweat as eccrine glands

• Apoeccrine

16

___________ glands Sweat is stickier, odorless (initially), then smells upon contact with skin flora, which is different than eccrine glands.

Apocrine

17

which inflammatory skin diseases are Staphylococcus aureus suggested to play a role in exacerbation of the disorder?

Bullous and non bullous imeptigo

- bullous for sure
strep can cause non bullous as well

18

Which skin disorder is associated with a history of asthma or hay fever (allergic rhinitis)?

Atopic dermatitis

19

atopic dermatitis
ichthyosis
both have in common what>?

Filaggrin mutation

20

A 5-year-old presents with itchy skin and has evidence of rash in the skin creases. His Mom says he’s always had dry skin. He has a history of asthma. Which of the following is MOST associated with his condition?

Filaggrin mutation – atopic dermatitis!!!!

21

Comorbidities associated with psoriasis?

including arthritis and increased cardiovascular risk.

22

Bowen’s disease (squamous cell carcinoma in situ) is linked to __________

human papilloma virus (HPV) infection.

23

Kaposi's sarcoma is linked to __________

HHV8 virus

24

Which benign skin tumors is associated with high levels of GLUT-1 expression (a placenta-associated marker)?

. Infantile hemangioma

25

Sudden appearance of multiple of which of the following benign skin tumors may be associated with adenocarcinoma of the stomach?

Seborrheic keratosis

- remember lesser trelat?

26

a Tzanck smear detects which viruses?

VZV, HSV

NOT HPV

27

The appearance of grouped vesicles/pustules on the fingertips is most consistent with ______ infection

HSV

28

The appearance of vesicles on an erythematous base is associated with _____ or ____ but not _____ infections.

HSV or VZV


not HPV

29

A 6-year-old boy presents with annular, scaly patch on his arm. KOH prep of skin scraping from the leading edge of the lesion reveal hyphae. Which of the following organisms is the MOST likely etiology of his skin condition?

Trichophyton rubrum - cutaneous

30

What bacteria causes syphilis?

Treponema pallidum

31

Ehlers-Danlos syndrome

Ehlers-Danlos syndrome - think contortionist (congenital collagen production mutation)

32

Melanocytes are located in which layer of the epidermis?

basal layer

33

What is the thickest layer of the epidermis?

Stratum spinosum

34

The majority of BCCs have a loss of what fxn?

PTCH (which normally blocks SMO)

- treat with vismodegib

35

Almost all moles that can lead to malignant melanoma have a mutation in what?

BRAF

-treat with vemurafenib