Arthritis

Question 0

Felty’s syndrome?

Answer 0

RA

splenomegaly and granuloycytopenia

Question 1

Asymmetric arthritises?

Answer 1

JIA, ankylosing spondylitis, OA

Question 2

Uveitis in?

Answer 2

JIA (ANA+), psoriatic arthritis, ankylosing spondylitis

Question 3

RA- features

Answer 3

feltys syndrome
pleural/cardiac effusions
anemia
psoriasis
Rhematoid nodules

Question 4

Inflammatory arthritises

Answer 4

RA, JIA, psoriatic, ankylosing spondylitis

Question 5

Features of JIA-

Answer 5

Uveitis (female, young, ANA+), llimb lenghth discrepancy, micrognathia (TMJ), bony knee enlargemets, enthesitis

Question 6

Quotidian fevers in what arhirits?

Answer 6

systemic JIA

Question 7

Systemic JIA features

Answer 7

Quotidian fevers, rash evanescent, hepatosplenomegaly

no enthesitis!!

Question 8

Psoriatic arthritis features

Answer 8

uveitis, nails (scaly plaques), enthesitis

Question 9

Spondylosing arthritis features

Answer 9

uveitis, urethritis/cervicitis, symdesmophytes (bamboo spine), enthesitis, dactylitis

Question 10

Does spondylosing arthritis get better or worse with activity

Answer 10

better wwith activity

Question 11

DMARDS treat?

Answer 11

RA
JIA
non axial ankylosing spondylitis

Question 12

HLA-B27?

Answer 12

ankylosing spondylosis

Question 13

ACCP?

Answer 13

RA, JIA <10%

Question 14

RF elevated in?

Answer 14

RA, <10% JIA

Question 15

Gender bias in arthritis?

Answer 15

RA- women
psoriatic- equal
ankylosing spondylitis- men
Gout- men, menopausal women

Question 16

Biologics (anti-TNF) can be used in what arthritises?

Answer 16

RA, some JIA, ankylosing spondyylitis

Question 17

Acute vs chronic arthritis time frames?

Answer 17

6 weeks chornic

Question 18

What needs to be ruled out for arhtirits diagnosis?

Answer 18

Infection

Gout/Pseudogout

Question 19

Arthrocentesis features

Answer 19

opaque- infllammatory
viscosity loss - inflammatory
blood- hemorrhage (pigmented villonodular synovitis, clot DO, trauma)

Question 20

Important antibodies for arhtritis

Answer 20

RF- IgG (worse prognosis in RA, JIA)
ACCP- worse prognosis in RA
ANA- JIA worse prognosis

Question 21

Reasons for uric acid underexcretion

Answer 21

renal insufficiency
diuretics
low dose ASA
HTN
cyclosporine
ketoacidosis
lead nephropathy
estrogen loss

Question 22

main players in uric acid excretion

Answer 22

GI tract

kidney (main)

Question 23

enzyme abnormalities responsible for uric acid overproduction

Answer 23

Lesch-nyan syndrome- HGPRT deficiency
PRPP synthetasee overactivity

ethanol/hypoxia, glycogen storage disease, psoriasis, hemolysiis, lymphoproliferative disease

Question 24

Triggers for gout attack

Answer 24

surgery, alcohol, increased purine diet, fluctuating uric acid levels

Question 25

Tophi?

Answer 25

seen in chronic gout | urate crystal deposit (olecranon, patellar tendon, achilles, ear)

Question 26

Gout crystals

Answer 26

needle | negative birefringement

Question 27

Rat bite erosions seen in?

Answer 27

radiograph of Gout

Question 28

Normal uriic acid levels

Answer 28

6mg/dL

Question 29

Losartan is..

Answer 29

probenicid

Question 30

Gout: eat, dont eat

Answer 30

cherries, dairy | alcohol, shellfish, organ meat, fructosee

Question 31

CPPD common joints

Answer 31

knee, shoulder, wrist, pubic symphysis

Question 32

Familial CPPD

Answer 32

ANKH gene (<55yr polyarticular)

Question 33

Pseudogout associated conditions

Answer 33

hyperPTH, hypoTh, renal insufficiency, hypophotameia, hypomagensimia, lymphoproliferative DO, hemochromatosis, hemosiderosis

Question 34

CPPD crystals

Answer 34

rhomboid | positive birefringement

Question 35

CPPD radiograph

Answer 35

white calcified cartilage

Question 36

CPPD treatment

Answer 36

none, manage inflammation (NSAID, colchine eh, steroids, analgesics))

Question 37

Spondyloarthropathies types

Answer 37

ankylosing, psoriatic arthritis, enteropathic (inflammatory bowel disease, oral ulcers), reactive arthritis (within month of infxn, GI/urethral/cervical)