Pharmacology

Question 0

Probenicid- what, how

Answer 0

• Gout, increase excretion

- bind/blocks URAT1 anion transporter protein, OAT in kidney brings from urine to plasma

Question 1

Colchicine- what? how? side effects?

Answer 1

• prophylactic, manage gout inflammation
• inhibit microtuule polymerization, inhiits neutrophil activation
• diarrhea

Question 2

Allopurinol- what how, side effects

Answer 2

gout, decreases production
xanthine analogue
dont take with azathioprine, mercaptopurine
steven johnsons syndrome

Question 3

Febuxostat- what how

Answer 3

decreasee production, gout

small molecule that inhibits xanthine oxidase

Question 4

Pegolated uricase- what how

Answer 4

gout, enhances metabolism of uric acid

oxidizes uric acid to allantoin

Question 5

Leflunomide- what how, side effects

Answer 5

DMARD (RA, JIA)
inhibts pyrimidine synthesis and dihydroorotate DH
nausea, diarrhea, bone marrow supression, hep, terateogenicity

Question 6

Sulfasalizine- what how side effectss

Answer 6

DMARD
mechanism unknwon
sulfa allergy, rash, nausea, bone marrow supression, diarrhea, hep

Question 7

Hydroxychloroquinee- how what, side effects

Answer 7

DMARD
inhibits TLR7/9 signlaing
nausea, HA, retinal pgimentation, hemolytic anemia