Asthma And COPD

Question 1

Ics - inhaled corticosteroids

Answer 1

Budesonide,fluticosone,beclometasone

Question 2

LABA- Long acting beta2agonist =

Answer 2

Formoterol,salmeterol

Question 3

SABA- Short Acting beta 2 agonist

Answer 3

Salbutamol,Terbutaline

Question 4

LTRA-Leukotriene Receptor antagonist -

Answer 4

Montelukast

Question 5

ICS/LABA Combinations -

Answer 5

Budesonide/formoterol, Fluticasone/salmeterol

Question 6

Long acting muscarinic antagonist - LAMA

Answer 6

Tiotropium

Question 7

COPD is about sputum, asthma is the inflammation.

Which combinations do we see being used in COPD?

Answer 7

SABA+ SAMA
LAMA+LABA
LABA+ICS

COPD ONLY:
- Methylxanthines:theophylline: used less commonly due to side effects but can provide bronchodillation

• Phosphodiesterase-4 inhibitors - Roflumilast - reduces the inflammation and may be used for severe COPD which chronic bronchitis

Question 8

SABA (Example,Indications,Contraindications,cautions,side effects,use)

Answer 8

-Salbutamol
- Quick relief of asthma symptoms
- Severe pre- eclampsia
- arrhythmias, hypokalaemia
-Fine tremors in hands, hypoklaamia, palpitations
- used when needed

Question 9

LABA (Example,Indications,Contraindications,cautions,side effects,use)

Answer 9

-formoterol, salmeterol,indacterol,vilanterol
- prevents asthma symptom
- severe re- eclampsia
- arrhythmias and hypokalaemia
- fine tremors, hypokalamia and palpitations
- used less commonly regularly

Question 10

Salbutamol - exam question

Answer 10

Fine tremor!!!

Question 11

Ics (Example,Indications,Contraindications,cautions,side effects,use)

Answer 11

• Beclomethasone, Budesonide, fluticasone
• Long term asthma control
• Contrainications apply to oral and iv use
• Oral candidiasis, voice alterations - low raspy sound
• rinse mouth after to prevent thrush

Question 12

SAMA (Example,Indications,Contraindications,cautions,side effects,use)

Answer 12

Ipratropium- quick relief of symptoms in COPD/Asthma
- no contraindications
- Prostativc hyperplasia
- Dry mouth and cough, headache
- Not commonly used in asthma

Question 13

LAMA (Example,Indications,Contraindications,cautions,side effects,use)

Answer 13

Aclidinium Glycopyrronium, Umeclinidium, Tiotropium
- Maintenance treatment in COPD
- Cystic fibrosis, tiotropium not given in under 6 years
- prostatic hyperplasia caution
- dry mouth, cough and headache
- tiotropium used in asthma and COPD, the rest only licensed for COPD

Question 14

LTRA (Example,Indications,Contraindications,cautions,side effects,use)

Answer 14

Montelukast
Asthma maintenance therapy
Contra- hypersensitivity
- caution in elderly
Se- abdominal pain, Churg Strauss syndrome, hepatoxicity
TAKE AT NIGHT

Question 15

Montelukast MHRA

Answer 15

CAN cause neuropsychiatric effects such as sleep disturbance, mood swings and agitations

Question 16

Xanthine - Theophylline

Answer 16

Asthma and stable COPD
By Brand
- Contra- COPD Exacerbations
- caution in arrhythmia and hypokalaemia
Side effects = nausea and vomitting, palpitations and hypokalaemia

Smokers= higher dose

Question 17

Theophylline + Beta 2 agonist

Answer 17

Increase hypokalaemia risk