Asthma/PE PBL Drugs Flashcards Preview

CRRAB II > Asthma/PE PBL Drugs > Flashcards

Flashcards in Asthma/PE PBL Drugs Deck (26):
1

1st Gen H1 antagonists (2)

cross BBB

**some anti-muscarinic effects

diphenhydramine

chlorpheniramine

2

2nd Gen H1 antagonists (3)

substrate for P-glycoprotein (actively pumped out of BBB)

fexofenadine

cetirizine

loratidine

3

Methylxanthine (similar to caffeine)

may be bronchodilatory

narrow therapeutic index

theophylline

4

Stabilizes Mast cells --> no degranulation

cromolyn sodium

5

non-selective adrenoreceptor agonist

B1, B2, a1

epinephrine

6

short acting beta-2 agonist

tolerance may develop w overuse (downregulation of B2's)

albuterol

7

long acting B2 agonist

toleance me develop w overuse

salmeterol

8

5-lipoxygenase inhibitor --> prevents leukotriene synthesis

**hepatotoxicity

zileuton

9

2 leukotriene receptor antogonists

zafirlukast

montelukast

10

Alpha-1 agonist

phenylephrine

11

a-1, a-2 agonist

pseudoephedrine

12

induce lipocortin to inhibit phospholipase A2 --> inhibits synthesis of cytokines

corticosteroids

betamethasone
dexamethasone
methylprednisolone
prednisone
triamcinolone
beclamethasone

13

binds circulating IgE and prevents it binding to mast cells and basophils

omalizumab

14

flunisolide

glucocorticoid receptor agonist

inhaled

15

budesonide

inhaled glucocorticosteroid

16

fluticasone

synthetic glucocorticosteroid

17

formoterol

long acting beta-2 agonist

18

pirbuterol

short acting B-2 agonist

19

inhibits vit-K dependent clotting factors:

II

VII

IX

X

protein C (inhibited first)

protein S

warfarin

20

increases anti-thrombin activity

decreases thrombin and factor Xa

Heparin

21

Similar to heparin but:

more Xa inhibition

longer half life

LMW heparin:

enoxaparin

dalteparin

22

direct Xa inibitors

apixaban

rivoroxaban

"xa" in the name

23

selective Xa inhibitor VIA anti-thrombin III:

fondaparinux

24

direct thrombin inhibitors (2):

argatroban

bivalirudin

25

stimulates conversion of plasminogen to plasmin....clot buster!

cleavage of fibrin mesh, destruction of coag factors

tPA

26

two drugs that block cys-LT1 receptors inhibiting mast cell and eosinophil activity:

montelukast

zafirlukast