Trachte Diuretics Flashcards Preview

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Flashcards in Trachte Diuretics Deck (42):
1

Two drugs that inhibit NKCC pump?

Furosemide

Bumetanide

2

Where is the NKCC pump?

Thick ascending loop of henle

3

How does the NKCC pump affect tubular fluid osmolality?

makes it hyPO-osmolar

**no aquaporins in thick ascending loop

4

Uses for loop diuretics?

pulm edema

edema

hyperkalemia

acute renal failure

anion OD

5

Chlorthalidone?

MOA

Blocks NaCl transporter in distal convoluted tubule

**a thiazide diuretic

6

HCTZ?

MOA

Blocks NaCl transporter in distal convoluted tuble

7

Metalazone?

MOA

Blocks NaCl transporter in distal convoluted tubule

thiazide diuretic

8

Thiazides used to treat?

HTN

CHF

nephrolithiasis caused by hypercalcemia

nephrogenic diabetes insipidus

9

Major side effect of Thiazides?

Hyperglycemia
-suppress insulin release

hypOkalemia

HLD

hypOnatremia

allergic RXN

10

What happens with thiazide + ACE inhib?

SYNERGY

RAAS perpetuation??

11

3 K sparing diuretics?

Spironolactone

Amiloride

Triamterene

12

ADH analogs (2)?

What do they do?

Vasopressin

desmopressin (synthetic)

recruit aquaporins in the medulla

13

Demecocycline?

antibiotic with ADH antagonism

14

Where does ADH originate?

hypothalamus/pituitary

15

What stimulates ADH release?

reduction in plasma volume

increase in plasma osmolality

16

What receptors are stimulated by ADH?

AVPR1--PI3/Ca-->vasoconstriction

AVPR2--cAMP-->insert aquaporins

17

Major osmotic diuretic not reabsorbed into the nephron:

mannitol

18

What is SGLT-2? Where is it?

sodium glucose transporter

proximal tubule

19

3 SGLT-2 transporter inhibitors:

"flozins"

Canigliflozin

Dapagliflozin

Gliflozin

20

Carbonic anhydrase inhibitor:

acetazolamide

blocks conversion of H2CO3 --> H20+CO2

21

Xanthine oxidase inhibitor?

allopurinol

reduces uric acid

22

Inhibit renal organic acid transporters (OATs) of urate to facilitate excretion (2):

Probenicid

Sulfinpyrazone

**proximal tubule

23

Net effect of thiazide diuretics on OATs?

increase blood uric acid

24

Actual channel blocked by Amiloride and Triamterene?

ENaC

25

Used to acidify urine?

Ammonium Chloride

26

Another drug for gout?

colchicine

27

Furosemide?

loop diuretic

28

bumetanide

loop diuretic

29

chlorthalidone

thiazide diuretic

30

hydrochlorothiazide

thiazide diuretic

31

metalozone

thiazide diuretic

32

spironolactone

Blocks Aldosterone receptor

K sparring diuretic

33

Amiloride

blocks ENaC

K sparring diuretic

34

Triamterene

blocks ENaC

K sparring diuretic

35

Antidiuretic hormone

increases aquaporin channels in collecting duct

concentrates urine

36

desmopressin

increases aquaporin channels in collecting duct

concentrates urine

37

Mannitol

exerts osmotic effect in proximal tubule to reduce water reabsorption

38

"flozins"

SGLT-2 inhibitors

reduce glucose reabsorption

39

Acetazolomide

carbonic anhydrase inhibitor

blocks reabsorption in prox tubule

**mostly used for glaucoma and excess CSF production

40

probenicid

suppresses urate reabsorption in the proximal tubule

41

sulfinpyrazone

suppresses urate reabsorption in the proximal tubule

42

allopurinol

suppresses uric acid formation