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Flashcards in Autonomic Pharm Deck (28):
1

sympathetic receptor on adrenal medulla:

nicotinic

2

NT stimulating nicotinic SNS receptor on adrenal medulla:

Acetylcholine

3

NT released from adrenal medulla in SNS response:

epinephrine

4

mechanism of a1 contraction of vascular smooth muscle:

(Gq) phospholipase C --> IP3 --> increased Ca++ concentration

5

NTs that stimulate a1's:

epi = NE >> isoproterenol

6

mechanism for SNS relaxation of bronchial SM via B2's:

(Gs) --> adenylyl cyclase --> cAMP --> PKA --> inhibits SM contraction

7

natural stimulus for B2 in the lung?

epinephrine

8

parasympathetic receptor on cell body of POST ganglioninc nerve:

nicotinic

9

parasympathetic receptor on end organs:

muscarinic

10

mechanism of PNS SM contraction via muscarinic receptors:

(M1, M3) Gq--> activation of Phospholipase C --> IP3 --> incr. Ca++ --> SM contract

or

(M2) Gi --> suppression of adenylyl cyclase activity --> decrease cAMP --> decrease PKA --> no activation of myosin light chain kinase (decreased atrial contractility and HR)

11

a1 agonist

phenylephrine

12

long acting B2 agonist

salmeterol

13

most common side effect of B2 agonists:

tremor (skeletal muscle B2 stim)

palpitations (B1 stim)

Headache

14

B2 agonist for non-asthma bronchospasm:

epinephrine

15

vasoconstrictor and weak B2 agonist

releases NE and has direct effect

Tx: bronchospasm, allergy

ephedrine

16

similar to ephedrine for nasal congestion

pseudoephedrine

17

short acting muscarinic antagonist:

ipratropium

18

long acting muscarinic antagonist:

tiotropium

19

Phosphodiesterase 4 inhibitor

increases cAMP/cGMP

Anti-inflammatory

suppression of cytokine release

inhibition of lung infiltration by neutrophils and other leukocytes.

Pulmonary remodeling and mucociliary malfunction are also attenuated.

romflumilast

20

Drug for BPH

causes mucosal stuffiness

whats the Mech?

terazosin

a1 blocker -- vasodilation

or prazosin (PTSD tx???)

21

non-selective, reversible a1 blocker

phentolamine

22

non-selective, IRreversible a1 blocker

phenoxybenzamine

23

Drugs that classically increase airway resistance in asthmatics via B2 antagonism:

beta-blockers

propanolol

timolol

pindolol

labetolol

metoprolol

atenolol

esmolol

24

causes cough and edema by inhibiting break down of bradykinin and preventing vasoconstriction:

ACE inhibitors (---prils)

25

NE depleting agent causing mucosal congestion

--can't vasoconstrict via a1

guanethidine

26

muscarinic agonist causing bronchoconstriction

bethanecol

27

anticholinesterase causing bronchoconstriction

neostigmine

28

how does inhibition of acetylcholinesterase cause bronchoconstriction?

PNS response is to constrict bronchiole SM via Ach and muscarinic receptors