TB-HIV-PBL Flashcards Preview

CRRAB II > TB-HIV-PBL > Flashcards

Flashcards in TB-HIV-PBL Deck (15)
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1
Q

Cause of pulm infx in HIV pt with normal CD4 count:

A

Strep pneumo

2
Q

Pulmonary infx in HIV pt with CD4

A
  1. Pneumocystis jirovecii pneumonia
  2. Histoplasmosis
  3. Toxoplasmosis
  4. Invasive Aspergillosis
3
Q

Pulmonary infx in pts with CD4

A
  1. Mycobacterium avium

2. CMV – interstitial pneumonia

4
Q

Positive predictive value = ?

A

true positives / (true positives + false positives)

5
Q

Used to treat TB

Decreases mycolic acid synthesis

A

Isoniazid

6
Q

Used to treat TB

inhibits DNA-dependant RNA-polymerase

A

Rifamycins

Ramps up p450

Red body fluids

Rapid resistance

RNA pol inhibitor

7
Q

Treats TB

blocks arabinosyltransferase –>

decreases carbohydrate polymerization

A

Ethambutol

8
Q

Vit B6 supplement

A

Pyridoxine

9
Q

What to give with Isoniazid?

Why?

A

Pyridoxine

prevents neurotoxicity

10
Q

HIV drugs

Protease inhibitors:

A

“navir’s”

Ritanovir

Indinavir

Amprenavir

Saquinavir

Lopinavir

Tipranavir

Atazanavir

11
Q

Why would you add low dose ritanovir to an HIV regimen?

A

CYP3A4 inhibitor –> “boosts” concentration of other drugs

12
Q

Immigrant TB screening in child less than 2:

A

none unless symptomatic or known contact

13
Q

Immigrant TB screening for ages 2-14:

A

TST/QuantGold, if + –> CXR, if + –> sputum smear/cx, if + –> drug sensitivity testing –> Daily observed therapy

14
Q

Immigrant TB screening fro ages 15 and older:

A

CXR, if + –> sputum smear/cultures, if + –> DST –> DOT

15
Q

Pts with HLA-B*5701 have delayed type hypersensitivity to which drug?

A

abacavir