Atypical antidepressant

Question 1

Atypical antidepressant drugs

Answer 1

Bupropion
Mirtazapine
Maprotiline
Trazodone

Question 2

Bupropion

Answer 2

Also for smoking cessation

MOA: Increase NE and DA via unknown

Toxicity: stimulant effect (tachy, insomnia), HA
seizure in bulimic pt.

NO SEXUAL SIDE EFFECT

Question 3

Mirtazapine

Answer 3

MOA
Alpha2 antagonist (increase NE and serotonin)
Potent 5HT2 and 5HT3 antagonist

Toxicity: sedation (desirable in depressed with insomnia),
increase appetite, thus
weight gain (desirable in elderly or anorexic)
dry mouth

Question 4

Maprotiline

Answer 4

MOA: Blocks NE reuptake

Toxicity: sedation, orthostatic HTN

Question 5

Trazodone

Answer 5

MOA: inhibit serotonin reuptake

Used for insomnia, as high doses are needed for antidepressant effects

Toxicity: sedation, nausea, PRIAPISM, postural hypotension

“called trazoBONE due to male specific side effect”