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Flashcards in B&L Unit 2 Deck (33)
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1

Type 1 Response

IgE mediated. Cross linkage of adjacent IgE on mast cells that activates release granules and histamine in first phase.
Late phase occure 5 to 10 hours later.
Major treatment is avoidance. Epipen with epinephrin can help.
Ex. allergic reaction
Ex. serum sickness?
Ex. Asthma
Ex. Eczema
Ex. Hay Fever

2

Type 2 Response

Specific antibody mediated reaction via complement mediated damage or stimulatory hypersensitivity. Immunofluorescence as linear.
Ex. Myasthenia gravis
Ex. Graves disease
Ex. Hashimoto Thyroiditis

3

Type 3 Response

Immune complexes trapped in basement membrane of blood vessels. Immunofluorescence is lumpy bumpy. Causes lumpy bumpy glomerulus.
Ex. Lupus
Ex. Initial Hypersensitivity Pneumonitis (Famer's Lung)
Ex. Arthus Reaction
Ex. IgA Nephropathy
Ex. one shot serum sickness
Ex. Rheumatoid Arthritis (IgM against IgG)

4

Type 4 Response

T cell mediated.
Ex. TB Test
Ex. Contact Dermatitis (poison ivy)
Ex. Multiple Sclerosis
Ex. first set graft rejection
Ex. second set graft rejection
Ex. Sjogren Syndrome

5

DiGeorge

Parathyroid should be carefully evaluated. Thymus does not form correctly. PreT cells have nowhere to mature. Results in lack of mature T cells.

6

Myasthemia Gravis

Type 2 autoimmunity.
Autoantibody to acetylcholine receptor

7

Systemic Lupus Erythematosis

Type 2 autoantibody to dsDNA. Anti-nuclear antibody (ANA) will be present. Type 3 lumpy bumpy complexes present in glomerulus.

8

Rheumatoid Arthritis

Pollution is an important risk factor- it increases citrullinated proteins in the lung.
Mostly type 4 T cell damage.
Autoantibody is present (RF) but is not only factor. This is also type 2.

9

Celiac Disease

Type 4.
HLA DQ2 and DQ8. Body accidentally phagocytoses gluten with tissue transglutaminase 2 and presents it on MHC 2s. T cell mediated immunity to gliadin (wheat peptide).

10

Graves Disease

Type 2 hypersensitivity immune reaction. IgG antibody binds and activates TSH receptor and activates signaling pathway leading to hyperthyroidism.

11

Chronic Frustrated Immune Response

Body makes immune response to something that doesn't go away. Skewed toward inflammatory response and away from Tregs.
Ex. IBD, Crohn disease, celiac disease, chronic Be disease, psoriasis, periodontal disease

12

Acute Promyelotic Leukemia

Tx: all trans retinoic acid (ATRA)

13

Goodpasture Disease

Autoantibodies to the lung and kidney basement membranes (type 4 collagen).
Type 2 autoimmunity.
HLA DR2

14

Autoimmune Thrombocytic Purpura (ATP)

Antibodies destroy platelets.
Type 2 autoimmunity.

15

Autoimmune Hemolytic Anemia

Autoantigen to RBC antigen.

16

Hashimoto Thyroiditis

Type 2 & 4.
Body creates antibodies to thyroid antigens.
Causes hypothyroidism.
Includes T cell mediated destruction of thyroid.

17

Aire

Thymic transcription factor that affects gene expression that helps regulate and destroy T cells that attack self. Defect in aire leads to T cell mediated autoimmunity.

18

Dressler Syndrome

Post- MI autoimmune response.
Type 2.
Specific autoantibody against epitope in pericardial or myocardial antigens.

19

Chronic Be Disease

Type 4. Chronic frustrated immune response.

20

SCID

No B or T cells made.
X-linked: defect in gamma chain of IL2 receptor.
Autosomal recessive: adenosine deaminase (ADA) deficiency.

21

Brutons

No B cell development.
X linked: bruton's tyrosine kinase (BTK) is normally important in B cell signaling. Causes agammaglobulinemia.

22

X linked Hyper IgM

Defective class switching due to CD40/CD40L leads to high IgM with low IgG and IgA

23

Common Variable Immunodefiency

Unknown cause.
It is difficult for these pts to trigger antibody production by B cells.

24

Rheumatic Heart Disease

Autoantibody to laminin on heart valves.

25

Major Basic Protein

Secreted by eosinophils (attracted by EFC-A, mixture of leukotrienes and prostaglandins, is secreted from mast cells) as part of late reaction to parasites.

26

Job Syndrome (hyperIgE syndrome)

Autosomal dominant.
Develop hyperreactivity to own cells.
Inability to make IFN-gamma effectively leading to poor Th1 responses and predominance of Th2.

27

Selective IgA Deficiency

increased frequency and severity of allergies

28

Ataxia Teangiectasia

autosomal recessive

29

Wiskott-Aldrich Syndrome

X linked
platelet and B cell deficiency
eczema

30

Ankylosing Spondylitis

HLA-B27