B&L Unit 1 Flashcards Preview

Blood and Lymph Mine > B&L Unit 1 > Flashcards

Flashcards in B&L Unit 1 Deck (56)
Loading flashcards...
1

Ensures that each B cell expresses a unique antibody. Only one parental copy of the allele is expressed and other is silenced. Diploid organisms inherit one copy from each parent.

Allelic Exclusion

2

Mature B cell starts by making IgM & IgD membrane-bound antibodies. Later it may switch to IgG, IgE, or IgA. The V domain stays the same and the same but C region of heavy chain changes. Changes are irreversible.

Heavy Chain Class Switching

3

Immunity resulting from utilizing products of someone else's immune system. System is designed by mother nature. Ex. newborn who is breast feeding.

Natural, Passive Immunity

4

Immunity results from real-life exposure to pathogen. Longest lasting type of immunity.

Natural, Active Immunity

5

Immunity resulting from the use of immune serum or purified antibodies to protect a patient at risk from a particular disease.

Artificial, Passive Immunity

6

Immunity resulting from intentional immunization with vaccines, toxoids, or other antigenic preparations.

Artificial, Active Immunity

7

dsRNA. Molecules associated with groups of pathogens, that are recognized by cells of the innate immune system. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors (PRRs) in both plants and animals.

Pathogen-Associated Molecular Pattern

8

Primary cell type in germinal center of lymph node follicle. Clonal deletions of these developing cells occur in the bone marrow. After antigen stimulation, somatic hypermutation in these cells causes even greater receptor diversity. Produces antibodies.

B Cell

9

10 polypeptide chains. Major isotype in milk. Most important antibody in GI tract.

IgA

10

Mediates warm autoimmune hemolytic anemia. Activates complement. Crosses placenta to provide protection to fetus. Opsonizes targets for removal by phagocytes. Neutralizes viruses. Half life is 3 weeks.

IgG

11

Mediates cold autoimmune hemolytic anemia.

IgM

12

Involved in allergic reaction and parasite reaction. Mast cells have receptors for this antibody's Fc.

IgE

13

Part of antibody molecules that contacts the antigenic determinant.

Hypervariable Region

14

Allele of the antibody chains found in an individual.

Allotype

15

Cells that have antigen-specific receptors. Pokeweed mitogen stimulates cellular division.

T & B Lymphocytes

16

Lyses bacteria. Opsonizes bacteria. Attracts phagocytic cells. Can be activated in absence of antibody.

Complement

17

Immunity of this cell type involves: antigen, angry macrophages, inducer T cells (Th1), and secretion of lymphokines. May contain CD4 or CD8 proteins.

T Cells

18

Chemotactic for PMNs.

C5a, Leukotriene B4, IL8, bacterial product

19

Part of membrane attack complex that polymerizes in the membrane to form a transmembrane channel.

C9

20

Least abundant type of white blood cell in peripheral blood. 0.5% - 1% normal differential.

Basophil

21

Does not change when B cell switches from making IgM to IgG antibodies.

Light Chain

22

40% to 60% normal differential.

Neutrophils

23

20% to 40% normal differential.

Lymphocytes

24

2% to 8% normal differential.

Monocytes

25

1% to 4% normal differential.

Eosinophils

26

Young neutrophil. 0% to 3% normal differential.

Bands

27

Order of white blood cell differential percentages.

band < basophil < eosinophil < monocyte < lymphatic < neutrophil

28

Central lymphoid organs in humans.

Bone Marrow & Thymus

29

In order, gene segments of immunoglobulin heavy chain mRNA.

V, D, J, Constant

30

Acts as bridge between innate and adaptive immune system. Phagocyte. Antigen-presenting cell.

Dendritic Cell