Unit 3 Coagulation Flashcards Preview

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Flashcards in Unit 3 Coagulation Deck (45)
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1

Factors that require vitamin K:

Vitamin K activates clotting and fibrinolysis factors
factor II
factor VII
factor IX
factor X
protein C
protein S

2

PT/INR

-measures extrinsic pathway

3

aPTT

-take out tissue factor
-just have phospholipid
-measures intrinsic pathway

4

Hemophilia A

-deficiency in factor 8
-inc aPTT
-muscle bleeding, bruising

5

Hemophilia B

-deficiency in factor 9
-inc. aPTT
-muscle bleeding, bruising

6

Factor 5 Leiden

-mutation in factor 5 that inhibits it from getting inactivated by protein C
-inc. clotting

7

Von Willebrand Disease

-most common bleeding disorder
-VW factor stored in weibel pilate bodies
-treated with desmopressin (DDAVP) before procedures (only works type 1)
-Type 1- low amounts
-Type 2- nonfunctional
Type 3- not present at all

8

Bernard-Soulier

-deficiency of GP1B

9

Immune Thrombocytopenic Purpura (ITP)

-antibodies attack platelets
-acute and chronic
-tx: steroids, IVIG (overwhelms immune system), rituximab (lowers B cells), splenectomy

10

Bleeding Time Test

-does not diagnose factor deficiencies

11

Primary Hemostasis

-platelet plug formation
-measure with bleeding time or PFA100
-defects lead to mucocutaneous bleeding

12

prothrombin G20210A

x

13

Plasmin

The key enzyme responsible for clot digestion (fibrinolysis).
-plasminogen is incorporated into clots and is activated by tPA and uPA, and it becomes plasmin

14

D-Dimer Test

x

15

Glycoprotein 2b3a

x

16

Heparin

-cofactor for antithrombin which greatly increases its ability to inactivate thrombin
-works in intrinsic pathway
-effects are immediate
-safe in pregnancy
-protamine reverses unfractionated heparin
-unfractionated heparin inactivates thormbin and factor 10 (IV)
-low molecular weight heparin also possible- inactivates factor 10 (injection)
-can be reversed with protamine sulfate (opposite charge of heparin) (hep is -)
-heparin induced thrombcytopenia- antibodies attack platelet factor 4-heparin complexes- tx in future with argatroban or leparudin

17

Warfarin

-works on extrinsic pathway
-takes a while for effects to begin (4 or 5 days)
-teratodenic- do not use in pregnant people
-oral

18

Desmopressin

-DDAVP
-stimulates VWF
-temporarily stop sx of VW disease

19

Argatroban

-drug that would be given if heparin is not working

20

mucocutaneous bleeding

-associated with platelets, VWF, and adherance

21

Idiopathic Thrombocytopenic Purpura

-antibody mediated destruction of platelets

22

TTP

ADAM

23

lupus anticoagulant

-antibodies mess up aPTT making it appear long
-pt is actually at risk for clots
-do mixing tests to confirm

24

citrate in blood tests

-chelates calcium
-add calcium when ready to run test

25

intrinsic tenase complex

-factors 8, 9, 10
-activates factor 10

26

extrinsic tenase complex

-TF and factor 7
-activates factor 10

27

prothrombinase

-factor 5, factor 10, prothrombin (factor 2)

28

factor 13

-covalently binds fibrins together in clot
-measuring of D-dimer is measurement of two fibrins between crosslink

29

central enzyme in blood coagulation

-thrombin

30

protein C

-protein S is cofactor
-activated by thrombin thrombomodulin to APC
-secondarily activated by vitamin K