Leukemias Unit 2 Flashcards Preview

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Flashcards in Leukemias Unit 2 Deck (37)
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1

Categories of Non-Hodgkin Lymphomas

1. Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL)
2. Follicular Lymphoma (FL)
3. Mantle Cell Lymphoma
4. Burkitt Lymphoma

2

Subcategories of Burkitt Lymphoma

1. endemic
2. sporadic
3. immunodeficiency associated

3

Categories of Classical Hodgkin Lymphoma

1. Nodular Sclerosis
2. Lymphocyte Depletion
3. Lymphocyte Rich
4. Mixed Cellularity

4

Categories of Myeloproliferative Neoplasms

1. Chronic Myelogenous Leukemia (CML)
2. Polycythemia Vera (PV)
3. Primary Myelofibrosis (PMF)
4. Essential Thrombocytopenia (ET)

5

Categories of Plasma Cell Lymphomas/Neoplasms

1. Extraosseous
2. Plasma Cell Myeloma (multiple myeloma)
3. Solitary Plasma Cytoma
4. Monoclonal Gammopathy of Undetermined Significance (MGUS)

6

1. deletion of 13q14
2. trisomy chromosome 12
3. deletion of 11q22-q23
4. deletion of 17p13

Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

7

IGH/BCL2
t(14;18)(q23;q21)

Follicular Lymphoma (FL)

8

IGH/BCL1
t(11;14)(q13;q32)

Mantle Cell Lymphoma

9

IGH/MYC
t(8;14)(q24;q23)
T(15;17)

Burkitt Lymphoma

10

BCR/ABL1
t(9;22)(

1. Chronic Myelogenous Leukemia (CML)
2. B-ALL

11

JAK2

1. Polycythemia Vera (PV)- 99% of cases
2. Primary Myelofibrosis (PMF)-50% of cases
3. Essential Thrombocytopenia (ET)- 50% of cases

12

MLL
t(11;23)

1. B-ALL
2. Acute Myeloblastic Leukemia (AML)- kids, bad prognosis

13

ETV6 Runx1

B-ALL

14

Runx1Runx1

Acute Myeloblastic Leukemia (AML)- kids, favorable prognosis

15

RBM/MKL

Acute Myeloblastic Leukemia- (AML)- down syndrome, good prognosis, kids

16

PML/RARA t(15;17)

Acute Promyeloblastic Leukemia (APL)- adults, good prognosis, -tx w/ ATRA

17

CBFB/MYH

Acute Myeloblastic Leukemia (AML)- kids, basoeos

18

Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

-Avg Age: 65
-Sex: more common in males
-Immunophenotype: positive (CD5, CD19, CD23), weakly positive (CD20, surface immunoglobulin), negative (CD10, FMC7)
-Cytogenetics: deletion 13q14, trisomy chr. 12, deletion 11q22-q23, deletion 17p13
-Rate: indolent

19

Follicular Lymphoma (FL)

-Cell Affected: germinal center B cells
-Imunophenotype: BCL2
-Cytogenetics: IGH/BCL2
-Rate: indolent

20

Mantle Cell Lymphoma

-Avg. Age: 60
-Sex: Males
-Immunophenotype: cyclin D1 (BCL1)
-Cytogenetics: IGH/BCL1
-Rate: intermediate

21

Burkitt Lymphoma

-Avg Age: 4-7
-Immunophenotype: CD10, CD19, CD20, BCL6, MYC (negative for CD5, CD23)
-Cytogenetics: IGH/MYC
-Appearance: starry sky due to histocytes
-Rate: aggressive

22

CHL- Nodular Sclerosis

-Avg Age: young adult
-Sex: women
-Immunophenotype: CD15, CD30
-Appearance: RS cells, thick fibrotic bands, architectural effacement
-Cause: EBV (10-25% of cases)

23

CHL- Lymphocyte Depletion

-Immunophenotype: CD15, CD30
-Appearance: RS cells, few lymphocytes
-Cause: EBV

24

CHL- Lymphocyte Rich

-Immunophenotype: CD15, CD30
-Appearance: RS cells, mosly lymphocytes
-Cause: EBV

25

CHL- Mixed Cellularity

-Avg. Age: kids, and old people
-Immunophenotype: CD15, CD30
-Appearance: RS cells, mixed lymphocytes and eosinophils, no fibrosis
-Cause: EBV

26

MPN- Chronic Myelogenous Leukemia

-Cytogenetics: MUST have BCR/ABL
Tx: imatinib (gleevac)

27

MPN- Polycythemia Vera (PV)

-Cells Affected: trilineage (erythro, neutro, mega)
-Immunopathology: JAK2
-Cytogenetics: JAK2 (99% cases)
-Clotting common in splenic v, hepatic portal v, and mesenteric
-Tx: serial phlebotomy

28

MPN- Primary Myelofibrosis (PMF)

-Cells Affected: neutro, mega
-Cytogenetics: JAK2 (50% cases)

29

MPN- Essential Thrombocytopenia

-Cells Affected: thrombocytes
-Cytogenetics: JAK2 (50% cases)

30

PCN- Extraosseous

-Location: outside of bone (respiratory tract common)
-Avg Age: old people