Immunophenotype Unit 2 Flashcards Preview

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Flashcards in Immunophenotype Unit 2 Deck (19)
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1

CD20

mature B cells (expressed in chronic leukemia)

2

CD19

on all B cells regardless of maturity

3

CD34

immature cells regardless of lineage

4

TDT

hallmark lymphoblast marker (immature lymphocytes) (helpful for distinguishing lymphoid blast cells because TDT is not present in myeloid blasts)

5

CD3 and CD7

immature T cells

6

CD4

T helper cells

7

CD8

NK T cells

8

CD34 and CD117

expressed in acute myeloblastic leukemia (AML) (immature myeloblasts)

9

surface immunoglobulin

expressed on mature B cells

10

CD5

normally T cell marker, but present on B cells in SLL/CLL and mantle cell lymphoma

11

CD23

present in B cells in CLL/SLL (helps tell apart from mantle cell lymphoma)

12

CD10

germinal center B marker, present in follicular lymphoma and burkitt lymphoma

13

BCL6

surface marker that is present in germinal center B cells

14

BCL2

present in follicular lymphoma due to translocation

15

BCL1 (cyclin D1)

present in mantle cell lymphoma due to translocation

16

MYC

present in burkitt due to translocation

17

CD30

only in reed-sternberg cells

18

CD15

only in reed-sternberg cells

19

MPO & auer rods

MPO forms auer rods. Hallmark of myeloblast.