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CP Test 2 > B4-092 Lipoprotein Structure and Metabolism > Flashcards

B4-092 Lipoprotein Structure and Metabolism Flashcards

(64 cards)

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1
Q

degrades TGs remaining in LDL and chylomicron remnants

A

hepatic lipase

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2
Q

apoA-1 is found on

A

HDLs

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3
Q

activates LCAT

A

apoA1

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4
Q

apoB-100 is found on

A

LDL, VLDLs

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5
Q

binds LDL receptor

A

ApoB-100

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6
Q

ApoB-48 is found on

A

chylomicrons

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7
Q

mediates chylomicron secretion into lymphatics

A

apoB-48
apoE

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8
Q

ApoC-II is found on

A

chylomicrons, VLDL, HDL

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9
Q

lipoprotein lipase cofactor that catalyzes cleavage

A

apoC-II

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10
Q

apoE is found on

A

chylomicrons
VLDL
HDL

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11
Q

degrades TG in circulating chylomicrons and VLDL

A

lipoprotein lipase

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12
Q

degrades TGs remaining in IDL and chylomicron remnants

A

hepatic triglyceride lipase

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13
Q

catalyzes esterification of 2/3 plasma cholesterol

A

LCAT

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14
Q
  • regulation of LDL levels
  • redistribution of cholesterol
  • utilization of cholesterol
A

LDL receptors

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15
Q
  • uptake of cholesterol loaded chylomicron remnants and HDL
  • delivery of cholesterol to liver for excretion
A

LDL receptor related protein

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16
Q

selective uptake of cholesteryl esters

A

scavenger receptor

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17
Q
  • delivers dietary TGs to peripheral tissues
  • secreted by intestinal epithelial cells
A

chylomicrons

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18
Q

delivers cholesterol to liver in the form of chylomicron remnants

A

chylomicrons

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19
Q
  • delivers hepatic TGs to peripheral tissues
  • secreted by liver
A

VLDL

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20
Q
  • delivers TGs and cholesterol to liver
  • formed from degradation of VLDL
A

IDL

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21
Q
  • delivers hepatic cholesterol to peripheral tissues
  • formed by hepatic lipase modification of IDL in the liver and peripheral tissue
A

LDL

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22
Q

taken up by target cells via receptor mediated endocytosis

A

LDL

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23
Q
  • mediates reverse cholesterol transport from peripheral tissues to liver
  • secreted from both liver and intestine
A

HDL

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24
Q

plasma HDL is [….] related to risk of CVD

A

inversely

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25
elevated LDL is a major risk for
atherosclerosis
26
LDL not taken up by hepatic LDL receptors migrates into
vascular intima
27
oxidized LDL accumulates in foam cells and can damage intima via
foam cell necrosis
28
* caused by hepatic overproduction of VLDL * high TG
primary hyper triglyceridemia
29
caused by absent or defective LDL receptors or defective apoB-100 receptors
hypercholesterolemia
30
high cholesterol with normal TG
primary hypercholesterolemia
31
* accelerated atherosclerosis * xanthomas
hypercholesterolemia
32
* defects in apoE * increased chylomicrons and IDL-like particles
dysbetalipoproteinemia
33
* common disorder * often with obesity, hyperinsulinemia, glucose intolerance, HTN
familial combined hyperlipidemia
34
complex lipid profiles, elevated total cholesterol HDL often reduced
mixed hyperlipidemias
35
caused by defective ABCA1
tangier disease
36
statins
HMG CoA reductase inhibitors
37
efflux cholesterol across the canalicular membrane
ABCG5/G8
38
transport of bile acids into canaliculi
ABCB11
39
phospholipid floppase
ABCB4
40
tangier is caused by defective
ABCA1
41
what happens when ABCA1 is defective
cholesterol accumulates in cells because its not available to efflux it to HDL
42
reduced HDL, LDL and total cholesterol is characteristic of
Tangier disease
43
major apolipoprotein of HDL
apoA-1
44
cholesterol efflux from macrophages
ABCA1
45
phospholipid floppase in canalicular membranes of hepatocytes
ABCB4
46
bile salt export pump in canalicular membrane of hepatocytes
ABCB11
47
cholesterol efflux from hepatocytes
ABCG5/G8
48
dysfunction ApoA-1 will result in
decreased HDL no reverse pathway
49
dysfuctional ApoA-1 is a major risk factor for
CVD
50
* produced by enterocytes * carry dietary TGs to liver and periphery
chylomicrons
51
ligand for LDL receptor
ApoB-100
52
activates LCAT
ApoA-1
53
activates lipoprotein lipase
ApoC-II
54
ligand for SR-B1
apoE
55
acquires free cholesterol and transports it back to the liver
HDL
56
carry TGs from intestine
chylomicrons
57
carry TGs from liver
VLDL
58
transports cholesterol to peripheral tissues and potentially deposits some in capillaries
LDL
59
ApoA-1 activates
LCAT
60
apoB-100 is a ligand for
LDL receptor
61
apoE is a ligand for
LDL receptor SR-B1
62
contains mainly cholesterol esters
HDL
63
* produced by liver * important for transport of liver derived TGs
VLDL
64
made from VLDL loosing fatty acids and apolipoproteins
LDL

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