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GIR Test 4 > B5-046 Renal Pathology II > Flashcards

B5-046 Renal Pathology II Flashcards

(70 cards)

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1
Q

dominant features of nephritis

3

A
  • hematuria
  • declining GFR
  • “active” urine sediment
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2
Q

subset of nephritis with relatively rapid onset

A

rapidly progressive glomerulonephritis

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3
Q

morphologic correlate of RPGN

A

glomerular crescents

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4
Q

3 causes of RPGN

A
  1. anti-GBM (type II HSR)
  2. immune complex (type III HSR)
  3. ANCA (type II HSR)
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5
Q

classically associated with group A strep

A

post-streptococcal glomerulonephritis

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6
Q

when do post-streptococcal glomerulonephritis symptoms begin?

A

delay, usually about 2 weeks post infections

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7
Q

symptoms of post-streptococcal glomerulonephritis

A
  • gross hematuria
  • hypocomplementemia
  • decline in GFR
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8
Q

pathology of post-streptococcal glomerulonephritis

A

neutrophils, crescents

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9
Q

LM: glomeruli enlarged and hypercellular
IF: granular “starry sky” appearance due to IgG, C3 deposition along GBM and mesangium
EM: subepithelial immune complex humps

A

post-streptococcal glomerulonephritis

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10
Q

IF: IgG, C3
EM: subepithelial humps

A

post-streptococcal glomerulonephritis

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11
Q
  • LM: crescent moon shape
  • crescents consist of fibrin and plasma proteins with glomerular parietal cells, monocytes, and macrophages
A

RPGN

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12
Q

linear IF due to antibodies to GBM and alveolar basement membrane

A

Goodpasture

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13
Q

hematuria associated with simultaneous URTI

A

IgA nephropathy

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14
Q
  • most common in young males
  • normal complement levels
A

IgA nephropathy

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15
Q

episodic hematuria that occurs with RTI or GI infection

A

IgA nephropathy

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16
Q

LM: mesangial proliferation
IF: IgA based immune complex deposits in mesangium
EM: mesangial immune complex deposition

A

IgA nephropathy

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17
Q

IF: mesangial IgA deposition
EM: mesangial electron dense deposits

A

IgA nephropathy

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18
Q

Henoch-Schonlein tetrad

A
  • nephritis
  • rash
  • arthritis
  • purpura
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19
Q
  • patient under 10 years old
  • pathology more likely to have crescents but otherwise indistinguishable from IgA nephropathy
A

Henoch-Schonlein

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20
Q

multi-system autoimmune disorder common in young females

A

lupus nephritis

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21
Q
  • variable presentation including both nephritic and nephrotic syndromes
  • 6 different morphologic patterns
  • proliferative lupus nephritis (class III and IV)
A

lupus nephritis

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22
Q

which classes of lupus nephritis are considered proliferative?

A

III and IV

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23
Q

IF: “full house”
EM: deposits in all glomerular compartments, esp subendothelial

A

lupus nephritis

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24
Q

nephritic syndrome that often copresents with nephrotic syndrome

A

membrano-proliferative glomerulonephritis

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25
Ig+ associated with antigen excess due to infection like HCV or HBV
membrano-proliferative glomerulonephritis Type 1
26
Ig- associated with abnormal alternative complement activation
membrano-proliferative glomerulonephritis Type 2
27
can be secondary to hepatitis B or C, may also be idiopathic
membrano-proliferative glomerulonephritis Type I
28
associated with low C3 nephritic factor
membrano-proliferative glomerulonephritis Type II
29
* mesangial ingrowth causes GBM splitting * "tram track" on H&E and PAS stains
membrano-proliferative glomerulonephritis
30
which type of membrano-proliferative glomerulonephritis has subendothelial immune complex deposits with granular IF?
Type I membrano-proliferative glomerulonephritis
31
which type of membrano-proliferative glomerulonephritis causes intramembranous deposits (also called dense deposit disease)?
Type II membrano-proliferative glomerulonephritis
32
LM: lobular hypercellularity, double contours IF: IgG and C3
Type I membrano-proliferative glomerulonephritis
33
LM: lobular hypercellularity, double contours IF: C3
Type II membrano-proliferative glomerulonephritis
34
auto-antibody to alpha 3 chain of type IV collagen
Goodpasture
35
* pulmonary-renal involement * typically young adult males
Goodpasture
36
LM: glomerular crescents, no arteritis IF: linear IgG and C3 in GBM
Goodpasture
37
associated with anti-neutrophil cytoplasmic antibodies | c-ANCA or p-ANCA
ANCA
38
causes systemic vasculitis affecting small arteries and glomeruli
ANCA
39
4 different ANCA syndromes
* GPA * MPA * EGPA * renal-limited
40
may result in RPGN | 2
ANCA Goodpasture
41
IF is "pauci-immune", meaning only minimal, non-specific staining
ANCA
42
negative IF with no IgC3 deposition
ANCA | pauci immune
43
inherited mutation in type IV collagen causing irregular thinning and thickening and splitting of GBM
Alport
44
* hematuria * deafness * chronic progressive renal decline
Alport
45
mutations associated with Alport
* COL4A5 (x linked) * COL4A3 (AD) * COL4A4 (AR)
46
* eye problems * glomerulonephritis * sensorineural deafness
Alport | cant see, cant pee, cant hear a bee
47
"basket" weave appearance due to irregular thickening of GBM
Alport
48
EM shows variable splitting, thinning of GBM
Alport
49
* indolent hematuria * AD inheritance * some patients found to have mutations in COL4A3 or 4 * EM show thin GBM
thin basement membrane disease
50
nephritic syndromes | 6
* PSGN * IgA nephropathy * RPGN * lupus nephritis * Alport * MPGN
51
Goodpasture | auto-antibody to COL4A3
52
PSGN
53
Alport
54
ANCA
55
lupus nephritis
56
Henoch-Shonlein or IgA nephropathy depending on age of patient
57
sinusitis that does not respond to therapy
GPA (ANCA)
58
ANCA vasculitis
59
nephrin and TRPC6 are mutated in
FSGS
60
variant alleles of APOL1 increase the risk of
FSGS | and HIVAN
61
auto-antibodies to PLA2R
primary membranous glomeruolpathy
62
MPGN
63
IgM, IgG, IgA, C3, an C1q deposits
lupus nephritis
64
IgA immune deposits
IgA nephropathy
65
shows IgG and C3 immune depositis
PSGN
66
* presents commonly in children * nephrotic and nephritic * C3 levels are low
dense deposit disease | MPGN Type II
67
membranoproliferative pattern with "sausage-like" dense deposits in GBM
dense deposit disease | MPGN Type II
68
Ig+ staining and subendothelial deposits
Ig+ MPGN
69
linear staining of GBM by IF
Goodpasture
70
synpharyngitic nephritis
IgA nephropathy

GIR Test 4 (18 decks)

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