Bacterial meningitis Flashcards Preview

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Flashcards in Bacterial meningitis Deck (17):

List some of the sequelae of acute bacterial meningitis

hearing loss, seizure, cognitive dysfunction


More than 80% of the cases of bacterial meningitis are caused by these three organisms:

Strep pneumoniae
Neisseria meningitidis
H influenza type b


List common and uncommon signs and symptoms of acute bacterial meningitis

Common: headache, fever, meningisumus, altered sensorium, Kernig's sign, Brudzinski's sign

Uncommon papilledema, seizures and vomiting are of intermediate frequency


Describe Kernig's sign

With the patient supine, flex the hip and knee each to about
90 degrees. With the hip immobile, attempt to extend
(straighten) the knee. In meningeal irritation, this attempt
is resisted and causes pain in the hamstrings.


Describe Brudzinski's sign

Place the patient supine and hold the thorax down upon the
bed. Attempt to flex the neck. In meningeal irritation, this
maneuver will cause involuntary flexion of the hips.


If possible, lumbar puncture should be obtained prior to initiation of ______



List typical findings in CSF for a person with acute bacterial meningitis

elevated opening pressure
high WBCs (neutrophils)
high protein
low glucose
positive gram stain (70%)
positive culture (70%)
bacterial antigen and PCR may be positive


List the three most common causes of meningitis in neonates

Strep agalactiae
E coli
Listeria monocytogenes


List the three most common causes of meningitis in children

Streptococcus pnumoniae
Neisseria meningitidis
Haemophilus influenzae type b


List the two most common causes of meningitis in adults

Neisseria meningitidis
Strep pneumoniae


List the five most common causes of meningitis in the elderly

Strep pneumoniae
Listeria monocytogenes
Neisseria meningitidis
Haemophilus influenza type b
Gram negative rods


List some of the supportive therapies commonly used to treat bacterial meningitis

fluid restriction (fluid resuscitation if the patient is in shock)
mannitol to increase oncotic pressure in the vasculature
corticosteroids prior to antibiotics- decrease inflammation and edema


What antibiotics are used to treat bacterial meningitis?

ceftriaxone + vancomycin

(ampicillin added in children less than 1 month old)


What drugs can be used for prophylaxis of close contacts of people with bacterial meningitis?

ciprofloxacin, rifampin or ceftriaxone


List features common to S pneumoniae, N meningitidis, and H influenzae

all have human reservoir
all are transmitted by respiratory droplets
all colonize the nasopharynx and can be cleared or carried asymptomatically
all cause similar clinical syndromes- meningitis, infection of lung, middle ear, sinuses, epiglottis
similar pathogenesis- encapsulated so can evade immune system


List additional virulence factors of Neisseria meningitidis (in addition to capsular polysaccharide)

IgA1 protease
LPS in the cell wall (gram -)
can activate complement cascade leading to DIC, Waterhouse-Friderichsen syndrome


List some characteristics of Listeria monocytogenes

Intracellular organism
tumbling motility
can cross placenta
virulence factor= listeriolysin O

causes neonatal sepsis (acquired in utero), meningitis (acquired during birth)