Bacterial Structure & Function Flashcards Preview

Term 4: Infectious Diseases > Bacterial Structure & Function > Flashcards

Flashcards in Bacterial Structure & Function Deck (14):
1

What does TLR 5 sense?

-Flagellin

2

Which TLR's can sense ss/ds RNA/DNA of viruses and bacteria?

TLR 3, 7, 8, 9

3

Which TLR's sense various membrane/wall components of gram + bacteria, mycobacteria, and yeast?

TLR 1, 2, 6

4

What is the structure of gram-negative bacteria?

Contain an inner membrane, surrounded by a thin cell wall that is encompassed by an outer membrane

5

What is the structure of gram-positive bacteria?

-single membrane surrounded by a thick cell wall

6

What is the mechanism of action of Vancomycin?

-it binds to C-terminal D-Ala-D-Ala of late peptidoglycan (gram +) precursors

-prevents reactions catalyzed by transglycosylases, transpeptidases, and the D,D-carboxypeptidases

7

How does LPS act as an endotoxin?

-in the bloodstream it can contribute to sever immune response resulting in septic shock

8

What portion of LPS can be modified to resist cationic peptide antibiotics?

-Lipid A moiety

9

What are the three main moieties of LPS?

-O-antigen

-Core Sugars

-Lipid A

10

What is flagellin?

-the protein that makes up the filament portion of the flagellum

-ligand for TLR5

11

What are the 5 common molecular targets of antibiotics in bacteria?

-Ribosomes

-RNA synthesis

-DNA gyrase

-Cell wall

-Folate Metabolism

12

What is a metatranscriptome?

-a collection of genes expressed in an environment

13

What is a pan-genome?

-a set of genes found in a particular bacterial species

14

How do bacteria develop resistant to vancomycin?

-Replace an alanine on peptidoglycan with lactate or serine