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Flashcards in Basal Ganglia Deck (17)
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1

BG fxn

initiate mvmts

2

parts of BG

striatum (caudate N. and putamen)
globus pallidus (in/ex)
substantia nigra
subthalamic N

3

parts of BG origins

striatum (telencephalon)
GP (telen)
SN (mid)
subthalamic (dien)

4

BG lesion (side)

contralateral

5

Parkinson's path

lewy bodies (defect in folding)
loss of pigmented dopa-neurons from SN
underactive motor cortex

6

most common BG disease

parkinsons

7

parkinsons Sx

"poverty of mvmt"

8

Parkinson's path

lewy bodies (defect in folding)
loss of pigmented dopa-neurons from SN
direct pathway lesion -->
underactive motor cortex

9

parkinsons Sx

"poverty of mvmt"
bradykinesia, pill-rolling (resting) tremor
shuffling gate
stooped posture

10

huntington disease mech

indirect path is lesioned
can't suppress unwanted mvmt
CAG repeat

11

huntington disease mech

indirect path is lesioned
can't suppress unwanted mvmt
CAG repeat
degen of GABA neurons in striatum
atrophy of caudate nuc

12

huntingtons sx

chorea (@ rest not when doing things)
personality cchanges
dementia

13

wilsons disease mech

both paths involved
copper accumulation
lesions in putamen

14

wilsons sx

wing beating tremor
parkinsons, chorea, liver

15

hemiballism mech

destroy STN
indirect pathway lesion
overactive motor cortex

16

hemiballism sx

wild fliging mvmts of limbs

17

hemiballism sx

wild flinging mvmts of limbs