Basic Principles

Question 1

most important limiting factor for permeation

Answer 1

lipid diffusion

Question 2

Through whivh blood vessels do drugs administered SL pass before reaching the heart?

Answer 2

lingual vein ➝ IJV ➝ brachiocephalic (innominate) vein ➝ SVC ➝ RA

Question 3

Type of antagonist

NE and phenoxybenzamine

Answer 3

non comp/ irrevesible

Question 4

Type of antagonist

histamine and epi

Answer 4

physiologic

Question 5

Type of antagonist

propranolol and TH

Answer 5

physiologic

Question 6

Type of antagonist

dimercaprol for lead poisoning

Answer 6

chemical

Question 7

Type of antagonist

pralidoxime for organophoshate poisoning

Answer 7

chemical

Question 8

idiosyncratic response to chloramphenicol

Answer 8

aplastic anemia

Question 9

idiosyncratic response to allopurinol

Answer 9

cataracts

Question 10

half life formula

Answer 10

(0.693 x Vd) /Clearance

Question 11

teratogenic effect of ACE inhibitors

Answer 11

fetal renal damage

Question 12

teratogenic effect of antiepileptic drugs

Answer 12

neural tube defects

Question 13

teratogenic effect of phenytoin

Answer 13

fetal hydantoin syndrome

Question 14

teratogenic effect of oral hypoglycemic agents

Answer 14

neonatal hypoglycemia

Question 15

teratogenic effect of barbiturates

Answer 15

neonatal dependence

Question 16

teratogenic effect of DES

Answer 16

vaginal clear cell CA

Question 17

teratogenic effect of lithium

Answer 17

Ebstein’s anomaly

Question 18

teratogenic effect of isotretinoin

Answer 18

craniofacial malformations

Question 19

teratogenic effect of iodide

Answer 19

congenital hypothyroidism

Question 20

teratogenic effect of misoprostol

Answer 20

Mobius sequence

Question 21

teratogenic effect of penicillamine

Answer 21

cutis laxa

Question 22

teratogenic effect of tetracycline

Answer 22

tooth discoloration

Question 23

teratogenic effect of methimazole

Answer 23

aplasia cutis congenita

Question 24

teratogenic effect of sulfonamides

Answer 24

kernicterus

Question 25

teratogenic effect of fluoroquinolones

Answer 25

cartilage damage

Question 26

teratogenic effect of warfarin

Answer 26

1st: chondroysplasia 2nd: CNS malformations 3rd: bleeding diathesis

Question 27

in vitro test for mutagenicity

Answer 27

Ames test - uses a special strain of Salmonella - loss of dependence ➝ mutation

Question 28

in vivo test for mutagenicity

Answer 28

dominant lethal test

Question 29

clinical phase trial? | is it safe? pharmacokinetics? 20-100 subjects

Answer 29

Phase 1

Question 30

clinical phase trial? | does i work in patients? 100-200 patients

Answer 30

Phase 2

Question 31

clinical phase trial? | does it work, double blind? 1000-6000 patients

Answer 31

Phase 3