BGM1002/L11 Carbohydrates II Flashcards

(30 cards)

1
Q

What is maltose?

A

Disaccharide of glucose + glucose
Major product generated from starch digestion

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2
Q

What is lactose?

A

Disaccharide of glucose + galactose
Milk sugar

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3
Q

What is sucrose?

A

Disaccharide of glucose + fructose
Transport form of carbohydrate from plants (table sugar)

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4
Q

Name 2 important energy storage molecules in the human body.

A

Starch
Glycogen

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5
Q

What types of glycosidic bond exist in starch and glycogen?

A

Alpha-1,4
Alpha-1,6

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6
Q

Where can starch be found? (2)

A

Plants
Human food sources

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7
Q

Where is glycogen found?

A

Animals

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8
Q

Which end of a polysaccharide is the reducing end?

A

Terminal in which C1 is unattached

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9
Q

Which end of a polysaccharide is the non-reducing end?

A

The terminal in which C1 is involved in a glycosidic bond
Cannot reduce other molecules

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10
Q

What causes some polysaccharides to twist into a helical structure?

A

Alpha-1,4-glycosidic bonds

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11
Q

Why is a helical structure favourable for sugars? (2)

A

More compact
Easily accessible

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12
Q

Where is cellulose found?

A

Plant cell walls

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13
Q

What causes cellulose chains to be planar?

A

Beta-1,4-glycosidic bonds

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14
Q

How do cellulose chains pack together?

A

Hydrogen bonds between chains

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15
Q

Where is peptidoglycan found?

A

Bacterial cell walls

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16
Q

What is a glycoconjugate?

A

A carbohydrate covalently bonded to other molecules e.g., proteins and lipids

17
Q

Give a function of glycolipids.

A

Receptors for cell recognition

18
Q

What are N- and O-linked glycoproteins

A

N- nitrogen-linked
O- oxygen-linked

19
Q

What 3 functions does N-glycosylation have?

A

Protein folding
Stability
Cell recognition

20
Q

What are N-linked glycoproteins attached to?

A

Amide group of asparagines

21
Q

What are O-linked glycoproteins attached to?

A

Hydroxyl group of serine or threonine

22
Q

What kind of glycosylation plays a role in mucins?

A

O-glycosylation

23
Q

What is a glycosaminoglycan?

A

Protein attached via O-linkage to polysaccharides

24
Q

Give 2 functions of proteoglycans.

A

Joint lubricants
Structural components of ECM
Mediate adhesion of cells to ECM
Bind factors that stimulate cell proliferation

25
Which component of proteoglycans determines function?
GAG
26
What are proteoglycans composed of?
Disaccharide repeats of amino sugar and uronic acid sugar
27
What is the function of glycotransferases?
Transfer of sugars from nucleotides onto other molecules
28
What is the initial step of a viral infection?
Binding of spike protein surface to human angiotensin-converting enzyme 2 (ACE2) receptor
29
What is passive 'antibody shielding'?
Antibodies bind to spike protein and 'block' interaction between virus and ACE2
30
What role do N-glycans play in RBD?
They stabilise the 'up' state of spike protein