blistering skin disorder / miscellaneous skin disorders Flashcards Preview

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Flashcards in blistering skin disorder / miscellaneous skin disorders Deck (67)
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1

blistering skin disorders - types

1. pemphigus vulgaris
2. Bullous pemphigoid
3. dermatitis herpetiformis
4. Erythema multiforme
5. Steven-Johnson syndrome

2

pemphigus vulgaris - mechanism

autoimmune skin disorder with IgG antibody against desmoglein (component of desmosomes) (stratum spinosum)

3

pemphigus vulgaris - appearance

Flaccid intraepidermal bullae caused by acantholysis
ORAL MUCOSA ALSO INVOLVED

4

pemphigus vulgaris - immunofluorescence

antibodies around epidermal cells in a reticular (net like) pattern

5

pemphigus vulgaris - sign

Nikolsky sign +

6

Nikolsky sign +

separation of epidermis upon manual stroking of skin

7

pemphigus vulgaris - course

potentially fatal

8

bullous pemphigoid - mechanism

IgG antibody against hemidesmosomes (epidermal basement mambrane)

9

bullous pemphigoid - Nikolsky sign

negative

10

bullous pemphigoid - immunofluorescence

linear pattern at epidermal-dermal junction

11

bullous pemphigoid - appearance

tense bilsters (CONTAINING EOSINOPHILS) affect skin but spares oral mucosa

12

dermatitis herpetiformis - appearance

pruritic papules, vesicles and bullae (often found on elbows)

13

dermatitis herpetiformis - pruritic papules, vesicles and bullae are often found on

elbows

14

dermatitis herpetiformis - associated with

celiac disease

15

dermatitis herpetiformis - mechanism

deposits of IgA at tips of dermal papillae (associated with celiac disease)

16

pemphigus vulgaris vs bullous pemphigoid - according course

pemphigus vulgaris --> potentially fatal
bullous pemphigoid --> less severe

17

pemphigus vulgaris vs bullous pemphigoid - according mechanism

pemphigus vulgaris --> IgG against desmoglein
bullous pemphigoid --> IgG against hemidesmosomes

18

pemphigus vulgaris vs bullous pemphigoid - Nikolsky sign

pemphigus vulgaris --> +
bullous pemphigoid --> -

19

pemphigus vulgaris vs bullous pemphigoid - immunofluorescense

pemphigus vulgaris --> reticular (net like)
bullous pemphigoid --> linear pattern

20

Erythema multiforme is associated with

1. infection 2. drugs 3. cancers 4. autoimmune diseases

21

Erythema multiforme - infections?

1. Mycoplasma pneumoniae
2. HSV

22

Erythema multiforme - drugs?

1. sulfa drugs
2. β-lactams
3. phenyntoin

23

Erythema multiforme - presents with

multiple types of lesions - macules, papules, vesicles, target lesions

24

Erythema multiforme - target lesions?

look like targets with multiple rings and dusky center showing epithelial disruption

25

Steven - Johnson syndrome is symptoms

1. fever 2. bullae formation 3. necrosis
4. sloughing of skin 5. targetoid lesions may appear

26

Steven - Johnson syndrome - prognosis

high mortality rate

27

Steven - Johnson syndrome - skin manifestations

1. bullae formation 2. necrosis
3. sloughing of skin 4. targetoid lesions may appear

28

Steven - Johnson syndrome - typically involves

2 mucous membranes

29

Steven - Johnson syndrome -targetoid skin lesions may appear, as seen in

erythema multiforme

30

Steven - Johnson syndrome is usually associated with (is a result of)

adverse drug reaction