Block 1 Lecture 2 -- IN, metabolism, PK, grapefruit, antihistamines, membranes Flashcards Preview

PHS 931 > Block 1 Lecture 2 -- IN, metabolism, PK, grapefruit, antihistamines, membranes > Flashcards

Flashcards in Block 1 Lecture 2 -- IN, metabolism, PK, grapefruit, antihistamines, membranes Deck (42)
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31

Characteristics of drug needed to cross BBB:

1) lipophilic/uncharged
2) MW

32

What percent of drugs on market cross BBB?

3%

33

Henderson Hasselbach equation

pH = pKa + log (A/HA)

34

pH of breast milk:

7.1

35

pH of blood:

7.4

36

pH of gastric juice:

1.4

37

What compounds have the greatest potential to concentrate in breast milk?

weak bases

38

Describe a nitrosation reaction.

Nitrite anion + 2º alkylamine --> N-nitrosamine

39

2nd gen. antihistamines are more selective for what receptors?

H1

40

MoA of naloxone:

competitive antagonist of mu-opioid receptor

41

Uses of naloxone:

-- reversal of opiate overdoses
-- coformulation with other opiate agonists

42

Why is naloxone co-formulated with oxycontin?

naloxone not absorbed via GI
-- can't get high if IV
-- decreases constipation and cramping