Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Flashcards Preview

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Flashcards in Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Deck (75)
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31

For what reasons weren't AAs accepted as NTs until 1980?

1) metabolic role
2) distribution
3) high concnetration
4) non-mammalian origin

32

What is the TA pair for glycine?

glyoxylate

33

What is the TA pair for glutamate?

alpha-KG

34

What is the TA pair for Asp?

OAA

35

What is the TA pair for GABA?

succinic-semialdehyde

36

Where does vigabatrin act?

inhibits GABA TA

37

What are the glutamate transporters?

1) EAAT1
2) EAAT2
3) EAAT3
4) EAAT4

38

Why are there so many Glu transporters?

high concentration of Glu as a NT

39

Where are EAAT1 GluTs located?

astrocytes

40

Where are EAAT2 GluTs located?

astrocytes
presynaptic

41

Where are EAAT3 GluTs located?

postsynaptic

42

Where are EAAT4 GluTs located?

postsynaptic

43

What are the predominant neurotransmitters in mammalian brains?

Glu + GABA

44

How are GluR's classified?

1) metabotropic
2) ionotropic

45

What are the metabotropic GluRs?

1) Group 1 Gq
-- 1,5
2) Group 2 Gi
-- 2,3
3) Group 3 Gi
-- 4,6,8,7

46

What are the ionotropic GluRs?

1) kainic acid
2) AMPAr
3) NMDAr

47

What does NMDA stand for?

n-methyl-D-aspartate

48

What does AMPA stand for?

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

49

Describe the permeability of the kainic acid receptor?

Na

50

Describe the permeability of the AMPAr?

Na

51

Describe the permeability of the NMDAr?

Ca

52

How is the NMDAr activated?

Gly and Glu
-- co-agonists

53

What are non-competitive antagonists of the NMDAr and where do they bind?

1) PCP/phencyclidine
2) ketamine
3) DM
4) memantine
-- bind in the channel

54

How is the NMDAr modulated?

1) directly by polyamines (spermine) and Zn
2) by increased activity, removing the Mg block

55

What is the function of the NMDAr Mg-block?

decreased activation of the NMDAr

56

Why does GABA have so many receptor subtypes?

highly flexible molecule with many different comformations

57

What are the GABA receptors?

1) GABAa (LGIC)
2) GABAb (Gi)

58

What are the subunits of the GABAa receptor?

many different alpha/beta
-- alpha 1-6
-- beta 1-3
-- wildcard d, e, g, t, pi

59

What are the 5 main domains of the GABAa receptor?

1) Cl- channel
2) GABA binding site
3) BZD binding site
4) barb/EtOH binding site
5) neurosteroid/volatile anesthetic binding site

--also: picrotoxin-binding site

60

Where is the GABA binding site on GABAa?

between a and b