Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Flashcards Preview

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Flashcards in Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Deck (75)
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61

Where is the BZD binding site on GABAa?

between a and g

62

What GABAa modulators bind in the channel?

1) barbs
2) steroids
3) picrotoxin

63

What GABAa modulators bind outside the channel?

GABA
BZDs

64

What is a GABAa agonist?

muscimol

65

What is muscimol?

GABAa agonist
-- poison native to KY

66

What are GABAa antagonists?

1) bicucline (competitive)
2) picrotoxin (non-competitive)

67

Describe the GABAb receptor.

metabotropic Gi
-- similar to a2 and M2 (presynaptic to decrease NT release)
-- high [GABAb] in spinal cord

68

What is a GABAb agonist?

baclofen

69

What is baclofen?

GABAb-selective GABAb agonist

70

What is glycine?

the main NT of renshaw cells in the vental horn of the spinal cord
-- co-agonist of NMDAr

71

What is a renshaw cell?

interneuron in ventral horn of SC
-- inhibits recurrent activity

72

Describe the glycine receptor, vesicular transport, and reuptake?

similar in structure/fx to GABAa
-- LGIC Cl
-- transported into vesicle via VGLYT
-- reuptake mediated by GLYT

73

Where does glycine bind on the NMDAr?

Gly B-site (strychnine-insensitive binding site)

74

What is a GlyR antagonist?

strychnine

75

What is strychnine?

GlyR antagonist
-- proconvulsant rat poison
-- emetic response in humans
-- does not act on Gly B-site of NMDAr