Flashcards in Block 2 Lecture 2 -- DA, 5HT, and Amino Acids Deck (75)
Where is the BZD binding site on GABAa?
between a and g
What GABAa modulators bind in the channel?
What GABAa modulators bind outside the channel?
What is a GABAa agonist?
What is muscimol?
-- poison native to KY
What are GABAa antagonists?
1) bicucline (competitive)
2) picrotoxin (non-competitive)
Describe the GABAb receptor.
-- similar to a2 and M2 (presynaptic to decrease NT release)
-- high [GABAb] in spinal cord
What is a GABAb agonist?
What is baclofen?
GABAb-selective GABAb agonist
What is glycine?
the main NT of renshaw cells in the vental horn of the spinal cord
-- co-agonist of NMDAr
What is a renshaw cell?
interneuron in ventral horn of SC
-- inhibits recurrent activity
Describe the glycine receptor, vesicular transport, and reuptake?
similar in structure/fx to GABAa
-- LGIC Cl
-- transported into vesicle via VGLYT
-- reuptake mediated by GLYT
Where does glycine bind on the NMDAr?
Gly B-site (strychnine-insensitive binding site)
What is a GlyR antagonist?