Flashcards in Blood Deck (19):
Haemopoiesis is what?
blood development, occurs continuously.
are platelets cells?
NO, takes 4-5 days to develop, lifespan of mature cells is 8-12 days
for each of the following state duration of development and lifespan of mature cell:
RBC: 5-7 days, 120 days
lymphocyte: 1-2 days, months/years
neutrophil: 6-9 days, 6hrs to few days
esinophil: 6-9 days, 8-12 days
basophil: 3-7 days, ?
monocyte: 2-3 days, months/years
which organs are hematopoietic?
mesoderm, liver and spleen, ossification of bone then marrow. cells are replaced continuously.
what is a pluripotent stem cell? if it takes lymphoid path what happens? myeloid path?
can become any of the different blood cells.
lymphoid: can only become a lymphocyte
myeloid: can become any of other cells except lymphocyte.
erythropoiesis is what?
RBC formation. we get a decrease in cell size throughout stages, loss of organelles, nucleus, cell division ceases, occurs in red bone marrow.
where is red bone marrow located?
skull, clavicle, ribs, sternum, ends long bones.
what is the smallest cell in your body?
erythropoiesis takes how long? what stage is when cell division completely stops? when do we have complete loss of nucleus?
reticulocyte (ribosomes still occur, they are lost in erythrocyte mature stage, when ribos are lost cell becomes esinophillic).
genesis of leukocytes occurs in which two lineages?
1. myelocytic: granulocytes and monocytes, occurs in bone marrow
2. lymphocytic: lymphocytes, once they leaves bone marrow they go to lymph glands, spleen and thymus where they mature.
what are the precursors in haemopoiesis? after this they become?
unipotent stem cells
"blasts": once cells become this form, they have features morphologically similar to that of a mature cell (therefore start committing)
what is CFU? what does it mean?
colony forming units, once cells become this they are committed to a particular cell line.
what are the general names of each stage after a blast?
"cell" stab cell
mature form of "cell"
(every cell goes through these with cell name in front, as they mature cell size decreases and increase in granules)
what is diapedesis?
movement of blood cells from colony into sinuses/capillaries (fenestrated)
how are platelets formed?
formed by large multinucleate cells= megakaryocytes (they bud off from these and go to capillaries). they contain four types of granules.
once cells are at "blast" stage are they committed?
lymphopoiesis is what?
progressive decrease in cell size, occurs in marrow and in immune tissues.
anemias are disorders of what cell type? common symptoms?
reduced RBCs, low hematocrit, low Hb, iron deficiency is most common cause, lack O2 bc Hb carrying capacity is altered.