Blood and Tissue Parasites (part III) Flashcards Preview

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Flashcards in Blood and Tissue Parasites (part III) Deck (39):
1

This is named after the gundi, a rodent in which it was first described

Toxoplasma gondii

2

Toxoplasma gondii: Responsible for ____

toxoplasmosis

3

Toxoplasma gondii: can infect a wide array of _______ hots

warm blooded

4

Toxoplasma gondii: Incidence of ______

toxoplasmosis- it produces mainly asymptomatic isease

5

Toxoplasma gondii: Epidemiology

Definitive hosts are domestic cats and their relatives. And intermediate hosts include rodents and birds

6

Toxoplasma gondii: transmission

Cat feces; uncooked meat, meat spread (very high prevalence in France-(85% seropositivity rate)-steak tartare; Can cross the placenta

7

Toxoplasma gondii: infectious forms caused by meat consumption

Tissue cyst

8

Toxoplasma gondii: infectious forms caused by cat poop consumption

Oocysts

9

Toxoplasma gondii: symptoms

most cases are asymptomatic; flu like illness; immunodeficient patients can develop CNS disease, pneumonitis, systemic disease

10

Toxoplasma gondii: Routine testing for diagnosis; IFA for IgM and IgG

Serology

11

Toxoplasma gondii: Microscopy diagnosis

-identify tachyzoites in some speciemens
-identify tissue cysts (contain bradyzoites)

12

Toxoplasma gondii: Describe tazhyzoites-active trophozites form seen through microscope

-Sausage shape forms (tend to round up if phagozytized)
-Have nucleus only (no kinetoplast; no undulating membrane)

13

Toxoplasma gondii: Describe bradyzoites-inactive tissue forms seen through microscope.

Many small, round, dot like forms found within tissue cysts; may become active trophs is cyst ruptures

14

Leishmania Species: Vector borne disease ______

sandflies (Lutzomyia and Phlebotomus spp)

15

Leishmania Species: Incidence of ____

leishmaniasis

16

Leishmania Species: Epidemiology- two forms

Two forms of leishmansiasis
-Visceral leishmaniasis & Cutaneous leishmaniasis

17

Leishmania Species: Transmission

By bite of sandflies

18

Leishmania Species: Infectious form

Promastigotes

19

Replication of organisms within the skin around where a sandfly has fed

Cutaneous leishmaniasis

20

This type of leishmaniasis causes dissemination of organisms to liver, spleen, bone marrow, Etc

Visceral

21

Leishmania Species: Diagnosis

Microscopy- examination of Giemsa-stained smears of bone marrow, tissue, etc. --Will see amastigotes in macrophages and outside of host cells

22

Leishmania Species: send to _____ lab for confirmation

CDC

23

Two types of disease caused in Trypanosoma species

Chagas disease (in the Americas)
African sleeping sickness (in Africa)

24

______ transmit chagas disease parasite

Triatomine beetles --Kissing bugs or Reduvild beetles

25

______transmit African sleeping sickness parasites

Tsetse flies (Glossina spp)

26

Trypanosoma species: distrubution

Parts of Africa, Latin America and even part of the US

27

Trypanosoma species: Incidence of ______

Trypanosomiasis

28

Trypanosoma species: Epidemiology and transmission-two forms

-African Sleeping sickness-Trypanosoma brucei gambiense and Trypanosoma brucei rhodesience
-Chagas disease-American trypanosomiasis caused by Trypanosoma cruzi

29

Trypanosoma species: Infectious form

Trypomastigotes

30

Trypanosoma species: infections they cause in African sleeping sickness

Chancre

31

Trypanosoma species: infections they cause in chagas disease

chagoma, cardiomyopathy

32

Trypanosoma species: symptoms in chagas disease

If trypomastigotes are introduced into the eye, the patient can develop Ramana's sign

33

Trypanosoma species: Diagnosis through microscopy and two forms found

-Examination of giemsa stained smears of blood, CSF and tissue; also histologic sections of muscle (Chagas)
-Trypomastigotes in fluids; Amastigotes in tissue cells

34

Microscopic characteristic of Trypanosoma cruzi-Tryptomastigote form

Found in blood; has nucleus and large kinetoplast at tip of tryptomastigote; less wavy, with C or U shape

35

Microscopic characterisic of Trypanosoma cruzi- Amastigote form

found in tissue; small, intacellular forms in macropahges or near disrupted cells. has nucleus and very small rod shaped kinetoplast

36

Microscopic characteristic of Trypanosoma gambiense/rhodesiense-Tryptomastigote form

Found in blood, CSF, BM, or Lymph nodes. ; Has nucleus and small kinetoplast at tip; is very wavy, with S or W shape

37

Three types of form found in Leishmania species during microscopy examination

Amastgote form (found in clinical specimens), Epimastigote (in cultures), and Trypomastigote forms (only in teh sandfly vector, not in humans)

38

Microscopic characterstics of Leishmania species- Amastgote form

Small forms, intracellular in, has nucleus and very small rod shaped kinetoplast

39

List the organisms that are vector borne disease

Trypanosoma species, Leishmania species, Babesia species