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Flashcards in Blood Cancers Deck (74)
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1

Which type of leukemia is unique in that it most commonly occurs in patients under 20 years of age?

Acute lymphocytic leukemia (95% under 20)

2

What is the term for increased lymphocytes? Decreased?

Increased = leukocytosis, Decreased = leukopenia

3

What is the general definition of leukemia?

Unregulated accumulation of immature cells in the marrow and lymph tissue

4

What is the usually number of WBCs per cubic millimeter of peripheral blood with leukemia?

Greater than 50,000

5

Is acute or chronic leukemia more common?

Acute slightly more

6

Does the presence or absence of blast and pros indicate acute leukemia?

Acute = presence, Chronic = absence

7

ALL demonstrates a proliferation of which cell type? AML?

ALL = lymphoblasts, AML = myeloblasts

8

Which is more likely to be fatal and therefore is more severe: acute or chronic leukemia without remission?

Acute (usually within 3 months)

9

What are possible predominate cell types seen with non-lymphocytic leukemia?

Neutrophils, eosinophils, basophils, and monocytes

10

What are the 4 major types of leukemia?

Acute lymphocytic (ALL), acute myeloid leukemia (AML), chronic lymphocytic (CLL), chronic myeloid (CML)

11

What is the gender bias for all leukemia types?

Males

12

Which cell type tends to be the most common predominate cell type with AML?

Neutrophils (assume this unless noted otherwise)

13

Is there a proliferation of blasts and pros for acute or chronic leukemia?

Acute!

14

What is another name for acute lymphocytic leukemia?

Acute lymphoblastic leukemia

15

What is the most common leukemia in adults?

AML

16

What does decreased segs mean on a CBC?

Decreased neutrophils

17

What radiographic feature can be indicative of leukemia?

Radiolucent submetaphyseal band (also could be neuroblastoma, scurvy, syphilis)

18

The Philadelphia chromosome is indicative of which leukemia in 90% of cases?

CML

19

Which has a worse prognosis: CML or CLL?

CML

20

CML patients have low levels of which substance?

Alkaline phosphatase

21

Which patient has a better prognosis with CML: one with the Philadelphia chromosome or one without?

WITH

22

What is a leukemoid reaction?

An elevated white blood cell count/leukocytosis that is a physiological response to stress/infection (NOT actual leukemia)

23

What is another name for a myelocytic leukemoid reaction?

Neutrophilic leukemoid reaction

24

Neutrophilic leukemoid reaction mimics what type of leukemia?

CML

25

What characterizes a myelocytic leukemoid reaction?

Neutrophilia with a left shift

26

How can we differentiate CML from a myelocytic leukemoid reaction?

Alkaline leukocyte phosphatase levels, Philadelphia chromosome, bone marrow findings

27

What is the difference between alkaline leukocyte phosphatase levels comparing CML to a myelocytic leukemoid reaction?

Normal to elevated with leukemoid, Decreased with CML

28

What is the difference with the Philadelphia chromosome when comparing CML to a myelocytic leukemoid reaction?

Present with CML, Absent with leukemoid reaction

29

What is the difference with bone marrow findings when comparing CML to a myelocytic leukemoid reaction?

Present with CML, Absent with leukemoid reaction

30

When WBC count is below 50K, is it usually a leukemia or leukemoid reaction?

Usually leukemoid reaction....