Blood Cell Terminology and CBC Flashcards Preview

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Flashcards in Blood Cell Terminology and CBC Deck (54)
1

What is another name for platelets?

Thrombocytes

2

What is the function of thrombocytes?

Major component of clotting system, plug holes in blood vessels

3

What are white blood cells also named?

leukocytes

4

What is the difference between plasma and serum?

Serum does not contain clotting factors

5

What is hematocrit?

fraction of whole blood composed of RBCs

6

Why is RBC described as "biconcave disc"

Disc-shaped with central concavity on each surface

7

How does RBC generate ATP

Glycolysis

8

How large should the central pallor on a normal RBC be?

1/3 diameter

9

Which of the following does NOT have a segmented nucleus
a) neutrophils
b) eosinophils
c) basophils
d) lymphocytes

d)

10

What type of leukocyte contains an irregular shaped nucleus and vacuoles?

Monocyte

11

Which type of leukocyte is characterized by a dark nucleus that takes up most of cell?

Lymphocyte

12

What is the color of the granules in:
Eosinophils
Neutrophils
Basophils

Red
Purple
Blue

13

A _______ cell is a maturing neurophil and is characterized by a bent nucleus

Band

14

What do monocytes differentiate into?

Macrophages and Dendritic Cells

15

Which of the following secrete histamine?
a) eosinophils
b) basophils
c) monocytes
d) neutrophils

b)

16

Which of the following is the body's first response to trauma
a) eosinophils
b) basophils
c) monocytes
d) neutrophils

d)

17

True or false: Platelets have no organelles

false, have mitochondria

18

True or false: RBC count is naturally higher in men than women

true

19

Erythrocytosis, leukocytosis, and thrombocytosis may all lead to what?

Neoplasm

20

Thrombocytosis is a sign of ________

inflammation

21

Erythrocytosis causes a reaction to increased O2 demand called ____________

polycythemia

22

What is the formula for red cell distribution width?

RDW = SD/MCV * 100

23

Anemia can be caused by which of the following:
a) low RBCs
b) low HCT
b) low Hgb
e) all of the above

e)

24

How is hemoglobin measured in the lab?

RBCs are lysed then CN-containing reagent is added to form cyanmethemoglobin then absorption is assessed at 540 nm

25

Hematocrit is normally measured using

CALCULATIONS! total RBC volume / total blood volume

26

What is the difference between mean corpuscular Hgb and mean corpuscular Hgb concn?

First one is avg mass of Hgb per RBC, second one is concn of Hgb per RBC

MCH = HGB/RBC
MCHC = HGB/HCT or MCH/MCV

27

Under which condition would you see high side scatter?
1) high cell complexity
2) high granules
3) larger cells

1) complexity

28

Under which condition would you see high forward scatter?
1) high cell complexity
2) high granules
3) larger cells

3) larger cells

29

Under which condition would you see the "disco ball effect"?
1) high cell complexity
2) high granules
3) larger cells

2) granules

30

Define basopenia. Is it of clinical signifiance?

Too low basophils - often clinically insignificant

31

What is the standard blood smear and how do white cell nuclei appear?

Wright-Glemsa, appear blue-purple

32

Rouleaux formation, the coin-like stacking of RBC is due to increased ______________

serum proteins

33

Agglutination, the clumping of RBCs, is induced by _____________

antibodies

34

Define hypochromia

decreased hgb in RBCs, central pallor is >1/3 of diameter

35

Define anisocytosis

variation in cell size

36

Define Poikilocytosis

variation in shape of cells

37

Define anisopoikilocytosis

general sense of red cell variance

38

The ________ or __________ is seen in thalessemia, hemaglobinopathies and artifact

codocyte, target cell RBC

39

The __________ is seen in sickle cell anemia

drepanocyte

40

The _________ is seen in myelofibrosis and is shaped like a tear drop

dacrocyte

41

Describe the steps of red cell maturation that allow it to exit the bone marrow and enter circulation as reticulocytes

Begin in marrow as large nucleated cells, then nuclear shrinks and hemoglobin is added. RBC's eject the nucleus then enter circulation

42

What is polychromasia and when is it seen?

It is an increase in nucleated RBCs - seen in times of increased RBC production or marrow due to stress

43

What are Howell-Jolly bodies and what do they indicate?

Residual DNA from when RBC rejects nucleus that are normally removed by spleen
Indicates hyposplenic state

44

What are pappenheimer bodies and what do they indicate (2)?

Iron granules
Indicate problem in iron metabolism OR hgb synthesis

45

What is basophilic stippling? Where is this a common finding?

Presence of ribosomes that cannot be degraded
Common finding in lead poisoning

46

Name two RBC parasites

malaria
babesia microti

47

What is left-shift? What is another name for it?

Presence of immature granulocytes in circulation
AKA bandemia bc most common immature cell in circulation

48

What causes bandemia?

Infection, certain drugs, neoplasms or marrow stress states

49

What are blasts? Cancer of blasts is referred to as?

earliest marrow precursors, leukemia

50

What changes occur in reactive lymphocytes, seen in proinflammatory states?

Get more cytoplasm, can develop nucleoli, and make pseudopodia that hug neighboring RBCs

51

What are immature granulocytes often considered markers of?

early sepsis

52

Where are hypersegmented neutrophils seen?

folic acid or vitamin b12 deficiency

53

Clumping platelets =

spurious thrombocytopenia

54

What is borreliosis caused by?

circulating tick borne spirochetes