Blood Components and Deriviatives

Question 1

2 Fxn of Whole Blood

Answer 1

Replacement of O2 carrying capacity

Maintainance of Intravascular Vol.

Question 2

Fxn of Packed Red Blood Cell

Answer 2

To increase O2 carrying capacity of blood in patient with Acute Chronic Anemia who are symptomatic or at High risk for end organ damage

Question 3

Volume of Packed Red Blood Cell

Answer 3

260 ml

Question 4

A product in which all of the red cells and most of the plasma from the original unit remain

Answer 4

Whole blood

Question 5

Volume of Whole Blood

Answer 5

540 ml

Question 6

Packed RBC maybe prepared from whole blood by _______ or by ________

Answer 6

Overnight sedimentation or by Centrifugation using Heavy Spin

Question 7

Whole Blood Shell life for CPA-1

Answer 7

35 Days at 1-6*C

Question 8

Whole Blood Shell life for CPD

Answer 8

21 Days at 1-6*C

Question 9

In packed RBC what are the two symptoms of Acute Chronic Anemia mentioned

Answer 9

Syncope and Dyspnea

Question 10

Give example in Packed RBC for High Risk for end organ damage

Answer 10

Subcritical Coronary Atherosclerosis

Question 11

How many ml of Additive solution is added in the RBC

Answer 11

100ml

Question 12

Volume of RBC added with Additive solution

Answer 12

340ml

Question 13

3 Fxn/Uses of transfused Washed RBC

Answer 13

1. Prevention of recurrent or severe allergic reactions
2. Neonatal intrauterine transfusion
3. Prevention of anaphylactic reaction in IgA deficient patients

Question 14

Washed RBC volume

Answer 14

180ml

Question 15

Wahsed RBC Shelf Life

Answer 15

24hrs at 1-6*C

Question 16

3 Fxn/Uses of Frozen Deglyceralyzed RBC

Answer 16

1. Long Term preservation of RBC units with rare phenotype or autologous RBC units
2. Alternative to CMV seronegative unit emergencies
3. Decrease febrile transfusion reaction

Question 17

Removes >90% of WBC

Answer 17

Frozen Deglyceralized RBC

Question 18

Shelf life of Frozen Deglyceralized RBC

Answer 18

10 years at -65 to - 200 *C

Question 19

Shelf life of Frozen Deglyceralized RBC after washing

Answer 19

24 hrs at 1-6*C

Question 20

Volume of Frozen Deglyceralized RBC

Answer 20

250ml

Question 21

4 Fxn/uses Leukocyte Reduced RBC

Answer 21

1. Decreased the risk of alloimmunization to HLA antigens on leukocyte
2. Decrease Febrile Non-Hemolytic transfusion reaction
3. Reduce the risk of CMV infection
4. Decrease immunomodulation and may decrease the risk of prior transmission in B lymphocytes

Question 22

A product in which the leukocyte is reduce in the blood to prevent alloimmunization to HLA antigens

Answer 22

Leukocyte Reduce RBC

Question 23

Volume of Leukocyte Reduce RBC

Answer 23

Similar to Original Unit

Question 24

Shelf life of Leukocyte Reduce RBC

Answer 24

Similar to Original Unit if Closed system is used

Question 25

Two RBC are divided into two seperate RBC units of equal volume

Answer 25

Two/Double Unit RBC Apheresis

Question 26

Volume of Two Unit RBC apheresis

Answer 26

320ml

Question 27

True or False . Two Unit RBC apheresis is similar to Packed RBC

Answer 27

True

Question 28

Shelf life of Two Unit RBC

Answer 28

1 yr at 1-6*C

Question 29

Use if Bleeding due to quantitative and qualitative platelet disorders

Answer 29

Random Donor Platelet Concentrate

Question 30

Volume of Random Donor Platelet concentrate

Answer 30

50-70 ml

Question 31

Random Donor Platelet concentrate is used in Prophylaxis in __________ patients . Give also the value

Answer 31

Severe Thrombocytopenic Patients ( 5000-10 000/UL)

Question 32

Shelf life of Random Donor Platelet concentrate

Answer 32

5 days with constant gentle agitation

Question 33

Shelf life of Random Donor Platelet concentrate after pooling platelets pheresis

Answer 33

4 hrs

Question 34

Volume of Single Platelet

Answer 34

200-400 ml

Question 35

In Single Platelet what is the volume of plasma to maintain pH.

Answer 35

250ml to achieve pH above 6.2

Question 36

pH of Single Platelet

Answer 36

pH of above 6.2

Question 37

True or False . In Single Platelet indication is not similar to random donor platelets

Answer 37

False

Question 38

Shelf life of Single Platetlet

Answer 38

5 days @ 20-24*C with constant gentle agitation

Question 39

It is used when additional prevention of alloimmunization to HLA antigens or reduction of CMV infection risk is desired

Answer 39

Leukocyte Reduced Platelets

Question 40

Leukocyte Reduced Platelets indications

Answer 40

Per random donor or pheresis platelets

Question 41

In Leukocyte Reduced Platelets it is done immediately before transfusion ( 3 log Filtration)

Answer 41

Bedside filtration

Question 42

Volume of Granulocyte Pheresis

Answer 42

200-300ml

Question 43

Granulocyte Pheresis shelf life

Answer 43

24 hrs @20-24*C

Question 44

An apheresis product or component with only granulocytes and other WBC

Answer 44

Granulocytes pheresis

Question 45

It is used when specific coagulation factor deficiency where coagulation factors are not available

Answer 45

FFP Fresh Frozen Plasma

Question 46

Granulocytopenia with persistent fever or infection. Give na value of Granulocytes

Question 47

Fresh frozen plasma contains

Answer 47

All coagulation factors , Complement other plasma proteins

Question 48

Volume of Plasma Proteins

Answer 48

200-260 ml

Question 49

Shelf life of Plasma Proteins

Answer 49

1 year @ -18*C

Question 50

It is used when there is bleeding due to multiple coagulation factor Deficiency

Answer 50

Plasma Proteins