Blood Drugs to Know and MOA Flashcards Preview

Pharmacology II > Blood Drugs to Know and MOA > Flashcards

Flashcards in Blood Drugs to Know and MOA Deck (50):
1

protamine

tx of bleeding

2

Abciximab

Platelet Inhibitors

3

dalteparin

low molecular weight heparins ( anticoagulant)

4

these are all competitive , reversible inhibitors of thrombin

thrombin inhibitors

5

this platelet aggregration inh drug is a chimeric monoclonal Ab; binds to GP receptor and blocks binding of fibrinogen; very expensive ; adverse effect of bleeding

abciximab

6

warfarin ( Coumadin)

other anticoagulants

7

this thrombin inhibitor drug binds to antithrombin III ; leads to rapid inactivation of thrombin and factor Xa; Low molecular weights/antithrombin III complex only inactivates factor Xa

thrombin inhibitors - heparin

8

this anti bleeding med inhibits plasminogen activation

aminocaproic acid

9

rivaroxaban

anticoagulant ( Factor Xa inhibitor)

10

dabigatran ( pradaxa)

anticoagulant ( direct thrombin inhibitor)

11

this platelet aggre. inh inhibits phosphodiesterase III ; prevents degradation of cAMP; adverse effects of HA and GI effects ; CI in pts with CHF

cilostazol

12

reteplase

thrombolytic agents

13

darbepoetin

tx of anemia

14

these drugs prevent the binding of fibrinogen to the GP receptors on platelet surfaces ; inhibit cyclooxygenase 1 or block GP or ADP receptors

platelet aggregation inhibitors

15

these drugs all act either directly or indirectly to convert plasminogen to plasmin; as clot dissolves It can attract free platelets and cause further thrombosis

thrombolytic drugs

16

this specific drug inhibits vitamin K epo-xide reductase ( enzyme that regenerates Vit K) ; takes hours to work and is reversible with Vit K admin

warfarin

17

Desirudin

anticoagulant ( direct thrombin inhibitor)

18

erythropoeitin

tx of anemia

19

these platelet aggreg. inh specific drugs also block the GP receptor ; IV only

Eptifibatide and Tirofiban

20

urokinase

thrombolytic agents

21

eptifibatide

Platelet Inhibitors

22

bivalirudin

anticoagulant ( direct thrombin inhibitor)

23

lepirudin

anticoagulant ( direct thrombin inhibitor)

24

tenecteplase

thrombolytic agents

25

argatroban

anticoagulant ( direct thrombin inhibitor)

26

this thrombolytic drug forms active complex with plasminogen ; used within 4 hours of MI ; bleeding disorders common and is a foreign protein

streptokinase

27

this anti bleeding med antagonizes agents that interfere with vitamin K

vitamin K

28

enoxaparin

low molecular weight heparins

29

aminocaproic acid

tx of bleeding

30

ticagrelor

Platelet Inhibitors

31

tirofiban

Platelet Inhibitors

32

this platelet aggre. inh drug is a coronary vasodilator; it increases cAMP levels ; good in combo with other meds

dipyridamole

33

these drugs either inhibit the action of coagulation factors or interfere with the synthesis of the coagulation factors

anticoagulants

34

pentoxifylline

tx of sickle cell

35

prasugrel

Platelet Inhibitors

36

this thrombolytic drug binds to fibrin and converts tissue plasminogen to plasmin

tenecteplase

37

this drug inhibits COX-1 ( impedes platelet aggregation) ;

aspirin

38

hydroxyurea

tx of sickle cell

39

dipyridamole

Platelet Inhibitors

40

streptokinase

thrombolytic agents

41

ticlopidine

Platelet Inhibitors

42

clopidogrel ( Plavix)

Platelet Inhibitors

43

this thromboylytic drug is a product of recombinant tech; it rapidly activates plasminogen that is bound to fibrin in a thrombus; bleeding complications can occur; improved outcome if admin,. within three hours of ischemic stroke

alteplase

44

These drugs block ADP 2Y receptors ; inhibits expression of GP IIB/IIa receptors for fibrinogen

platelet aggregration inhibitors ( ticlopidine, Clopidogrel, Prasugrel, and Ticagrelor)

45

Aspirin

Platelet Inhibitors

46

alteplase

thrombolytic agents

47

fondaparinux

anticoagulant ( Factor Xa inhibitor)

48

this thrombolytic drug is produced by the kidneys; It directly cleaves the arginine- valine bond of plasminogen to yield plasmin; approved for lysis of pulmonary emboli

urokinase

49

heparin

other anticoagulants

50

this anti bleeding med antagonizes heparin

protamine