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Flashcards in drugs targeting central opiate systems Deck (27):
1

activation of these opioid receptor channels leads to opening of K channels

Mu/Delta

2

activation of these drug receptors leads to inhibition of adenylyl cyclase and a decrease in the concentration of cAMP

opioids

3

these drugs are used in the reversal of opiate overdose;

opiate receptor antagonist

4

fentanyl

opioid agonist

5

meperidine

opioid agonist

6

hydromorphone

opioid agonist

7

these drugs show agonist activity in drug naiive pts; they show antagonist activity in pts with opioid dependence

mixed agonist antagonist

8

methadone

opioid agonist

9

these drugs commonly used for pain control and as an anesthetic

morphine and fentanyl

10

hydrocodone

partial opioid agonist

11

Percodan ( oxycodone + acetaminophen)

common combo drug

12

morphine

opioid agonist

13

this drug selectively targets GI opiate receptors which is used to tx diarrhea

loperamide

14

lortab ( hydrocone + acetaminophen

common combination drug

15

buprenorphine

mixed agonist- antagonist

16

activation of these opioid receptors leads to less Ca influx into the pre synaptic nerve terminal

Kappa

17

oxycodone

opioid agonist

18

nalbuphine

mixed agonist- antagonist

19

Tylenol ( codeine + acetaminophen )

common combo drug

20

this drug binds to opioid receptor and weakly inhibits reuptake of NE and serotonin;

tramadol ( opioid receptor agonists)

21

tramadol

mixed mechanism

22

oxymorphone

opioid agonist

23

naloxone

opioid antagonists

24

Percocet ( oxycodone + acetaminophen)

common combo drug

25

heroin

opioid agonist

26

codeine

partial opioid agonist

27

levorphanol

opioid agonist